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Nephrogenic Diabetes Insipidus: A Rare Presentation in Multiple Myeloma | ||
Middle East Journal of Cancer | ||
مقاله 9، دوره 3، Issue 2-3، مهر 2012، صفحه 89-92 اصل مقاله (261.99 K) | ||
نوع مقاله: Case Report(s) | ||
نویسندگان | ||
Mehdi Dehghani* ؛ Vahid Mohammad Karimi | ||
Shiraz University of Medical Sciences, Hematology Research Center, Shiraz, Iran | ||
چکیده | ||
We report a case of multiple myeloma that presented with anorexia, fatigue, high erythrocyte sedimentation rate, bone marrow plasmacytosis of more than 30%, polyuria,and low urine specific gravity. This unusual presentation was diagnosed as nephrogenic diabetes insipidus secondary to a proximal tubular dysfunction. The tubular functional disturbance appeared to be related to the presence of lambda-type light chains. The patient was treated with desmopressine without response. After one month of treatment with thalidomide and dexamethasone for myeloma there was a dramatic response with decreased urine output. | ||
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