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Sayed, Heba, Sayed, Mona, El-Sayed, Mohamed. (1391). Combined Modality Therapy of Pediatric Wilms' Tumor in Upper Egypt: A Retrospective Study. سامانه مدیریت نشریات علمی, 3(4), 131-140.
Heba A. Sayed; Mona M. Sayed; Mohamed I. El-Sayed. "Combined Modality Therapy of Pediatric Wilms' Tumor in Upper Egypt: A Retrospective Study". سامانه مدیریت نشریات علمی, 3, 4, 1391, 131-140.
Sayed, Heba, Sayed, Mona, El-Sayed, Mohamed. (1391). 'Combined Modality Therapy of Pediatric Wilms' Tumor in Upper Egypt: A Retrospective Study', سامانه مدیریت نشریات علمی, 3(4), pp. 131-140.
Sayed, Heba, Sayed, Mona, El-Sayed, Mohamed. Combined Modality Therapy of Pediatric Wilms' Tumor in Upper Egypt: A Retrospective Study. سامانه مدیریت نشریات علمی, 1391; 3(4): 131-140.

Combined Modality Therapy of Pediatric Wilms' Tumor in Upper Egypt: A Retrospective Study

Middle East Journal of Cancer
مقاله 5، دوره 3، شماره 4، دی 2012، صفحه 131-140    اصل مقاله (349.89 K)
نوع مقاله: Middle East Special Report
نویسندگان
Heba A. Sayed1؛ Mona M. Sayed2؛ Mohamed I. El-Sayed* 2
1Pediatric Oncology Department, South Egypt Cancer Institute (SECI), Assiut University, Assiut, Egypt
2Radiation Oncology Department, South Egypt Cancer Institute (SECI), Assiut University, Assiut, Egypt
چکیده
Background: We conducted a retrospective analysis to investigate the clinical outcome of combined modality therapy using multiagent chemotherapy, nephrectomy, and radiotherapy in treatment of children with Wilms' tumor.Methods: This study was conducted on 91 cases of newly diagnosed Wilms' tumor from January 2001 until February 2012. Patients were categorized into two groups according to treatment approach: i) preoperative chemotherapy with delayed surgery (group A; n=66) and ii) immediate surgery (group B; n=25).Results: Preoperative chemotherapy showed a 54.5% partial response rate in group A patients. A final stage distribution indicated that the majority of patients (64%) from both groups were considered to be in the early disease stages (I and II). The median follow up was 49 months (range 3-124). The five-year overall survival rate was 66.5%, whereas the event-free survival rate was 62.5%. In univariate analysis, factors associated with statistically significant reduction in overall (P24 months was associated with a significant reduction in the overall survival rate (P=0.038, HR: 0.438, 95% CI: 0.192-0.953), but was not significant in terms of event- free survival (P=0.104, HR: 0.539, 95% CI: 0.256-1.136). Age >24 months (P=0.0095), disease stage (P=0.0014), and blastimal subtype (P=0.006) were associated with significant increases in relapse rate.Conclusion: Preoperative chemotherapy resulted in a final stage redistribution that placed the majority of patients in the early stages of the disease. Age at diagnosis, disease stage, and histological subtype significantly affected survival and relapse rates.
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