پیوندهای مفید
آمار
| تعداد نشریات | 20 |
| تعداد شمارهها | 1,089 |
| تعداد مقالات | 9,995 |
| تعداد مشاهده مقاله | 26,538,268 |
| تعداد دریافت فایل اصل مقاله | 7,303,485 |
Correlation of Serum Insulin-like Growth Factor 1 with Prostate Cancer | ||
| Middle East Journal of Cancer | ||
| مقاله 1، دوره 3، شماره 4، دی 2012، صفحه 95-99 اصل مقاله (264.19 K) | ||
| نوع مقاله: Original Article(s) | ||
| نویسندگان | ||
| Mohsen Ayati1؛ Shahryar Zeighami* 2؛ Majeed Safavi1؛ Mohammad Reza Nowroozi1؛ Hasan Jamshidian1؛ Alipasha Meysamie3 | ||
| 1Department of Urology, Uro-oncology Ward, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran | ||
| 2Department of Urology, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 3Department of Community and Preventive Medicine, Medical Faculty, Tehran University of Medical Sciences, Tehran, Iran | ||
| چکیده | ||
| Background: Insulin-like growth factor-1 can act in both an autocrine and paracrine manner to promote normal growth and malignant cellular proliferation. The importance of this factor as a major regulatory peptide has been established for cells, in vitro and in vivo. However, the role of serum insulin-like growth factor-1 levels in the etiology of benign prostatic hyperplasia and prostate cancer has not received sufficient attention. The aim of this study was to determine the relationship between benign prostatic hyperplasia, prostate cancer, and serum insulin-like growth factor-1 levels. Methods: We collected blood samples from 68 individuals with prostate cancer (cases) and 68 individuals with benign prostatic hyperplasia (controls) who were patients at Imam Khomeini Hospital in Tehran, Iran. Those with benign prostatic hyperplasia had normal prostatic specific antigen levels Results: Patients in the prostate cancer group had a mean age of 68 years, whereas those with benign prostatic hyperplasia had a mean age of 65 years (P>0.05). Mean serum insulin-like growth factor-1 levels were 219 ng/ml for the case group and 133 ng/ml for the control group, which was significant (P=0.0009). We did not observe any correlation between age and insulin-like growth factor-1 in the case group (P=0.83, r= -0.47), however there was a significant correlation in the control group (P=0.007, r=0.549). Although correlation between prostate volume and serum insulin-like growth factor-1 levels was not statistically significant in the case group (P=0.38, r=0.213), there was a positive correlation observed in the control group (p <0.008, r=0.537). Conclusion: Our findings suggest that insulin-like growth factor-1 may have an etiologic role in prostate cancer. This interpretation is strengthened by the significant difference observed between serum insulin-like growth factor-1 levels in benign prostatic hyperplasia and prostate cancer patients. These results also offer additional opportunities for evaluating patients who have abnormal digital rectal exams or prostate specific antigen levels, yet their biopsies are normal. Under these circumstances, measurement of serum insulin-like growth factor-1 may assist with the decision for a second biopsy. | ||
| کلیدواژهها | ||
| Insulin-like growth factor؛ BPH؛ Prostate cancer | ||
|
آمار تعداد مشاهده مقاله: 16,078 تعداد دریافت فایل اصل مقاله: 6,321 |
||