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Shabanizadeh, Ahmad, Dahim, Hajar, Salahshoor, Reza, Taghipour, Zahra, Taghavi, Mohammad Mohsen, Gafarineveh, Hamidreza, Eslami, Bahram, Babazadeh, Zahra, Fatehi, Farangis. (1391). Promoter Methylation Status and Protein Expression of BRCA2 in Patients with Epithelial Ovarian Cancer. سامانه مدیریت نشریات علمی, 4(1), 15-20.
Ahmad Shabanizadeh; Hajar Dahim; Reza Salahshoor; Zahra Taghipour; Mohammad Mohsen Taghavi; Hamidreza Gafarineveh; Bahram Eslami; Zahra Babazadeh; Farangis Fatehi. "Promoter Methylation Status and Protein Expression of BRCA2 in Patients with Epithelial Ovarian Cancer". سامانه مدیریت نشریات علمی, 4, 1, 1391, 15-20.
Shabanizadeh, Ahmad, Dahim, Hajar, Salahshoor, Reza, Taghipour, Zahra, Taghavi, Mohammad Mohsen, Gafarineveh, Hamidreza, Eslami, Bahram, Babazadeh, Zahra, Fatehi, Farangis. (1391). 'Promoter Methylation Status and Protein Expression of BRCA2 in Patients with Epithelial Ovarian Cancer', سامانه مدیریت نشریات علمی, 4(1), pp. 15-20.
Shabanizadeh, Ahmad, Dahim, Hajar, Salahshoor, Reza, Taghipour, Zahra, Taghavi, Mohammad Mohsen, Gafarineveh, Hamidreza, Eslami, Bahram, Babazadeh, Zahra, Fatehi, Farangis. Promoter Methylation Status and Protein Expression of BRCA2 in Patients with Epithelial Ovarian Cancer. سامانه مدیریت نشریات علمی, 1391; 4(1): 15-20.

Promoter Methylation Status and Protein Expression of BRCA2 in Patients with Epithelial Ovarian Cancer

Middle East Journal of Cancer
مقاله 3، دوره 4، شماره 1، فروردین 2013، صفحه 15-20    اصل مقاله (343.97 K)
نوع مقاله: Original Article(s)
نویسندگان
Ahmad Shabanizadeh* 1؛ Hajar Dahim2؛ Reza Salahshoor3؛ Zahra Taghipour1؛ Mohammad Mohsen Taghavi1؛ Hamidreza Gafarineveh1؛ Bahram Eslami4؛ Zahra Babazadeh5؛ Farangis Fatehi6
1Department of Anatomy, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
2Department of Pathology, Shahid Beheshti Hospital, Isfahan, Iran
3Department of Anatomy, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
4Department of Anatomy, Faculty of Nursing, Kashmar University of Medical Sciences, Kashmar, Iran
5Department of Anatomy, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
6Department of physiology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
چکیده
Background: Ovarian cancer is the leading cause of death among gynecological cancers. Changes in the methylation of BRCA1 and BRCA2 may be an effective mechanism for breast and ovarian cancer. This study evaluates the protein expression and methylation status of BRCA2 in Iranian patients.Methods: We assessed 60 Mullerian-type ovarian cancers by methylation-specific PCR assays and immunohistochemistry.Results: According to methylation status analysis, there were 7 of 60 (11.66%) methylated cases that had low protein expression.Conclusion: We concluded that changes in the methylation status of BRCA2 cannot be used as an appropriate biomarker to ascertain the development of ovarian cancer.
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