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Owrangi, Bahareh, Habibagahi, Mojtaba, Hosseini, Ahmad, Fazelzadeh Haghighi, Negin, Mardani, Mohsen, Talei, Abdolrasoul, Ghaderi, Abbas, Jaberipour, Mansooreh. (1391). MDM2, E-cadherin, Survivin and Her2 mRNA Status in Peripheral Blood of Patients with Breast Cancer. سامانه مدیریت نشریات علمی, 4(1), 7-14.
Bahareh Owrangi; Mojtaba Habibagahi; Ahmad Hosseini; Negin Fazelzadeh Haghighi; Mohsen Mardani; Abdolrasoul Talei; Abbas Ghaderi; Mansooreh Jaberipour. "MDM2, E-cadherin, Survivin and Her2 mRNA Status in Peripheral Blood of Patients with Breast Cancer". سامانه مدیریت نشریات علمی, 4, 1, 1391, 7-14.
Owrangi, Bahareh, Habibagahi, Mojtaba, Hosseini, Ahmad, Fazelzadeh Haghighi, Negin, Mardani, Mohsen, Talei, Abdolrasoul, Ghaderi, Abbas, Jaberipour, Mansooreh. (1391). 'MDM2, E-cadherin, Survivin and Her2 mRNA Status in Peripheral Blood of Patients with Breast Cancer', سامانه مدیریت نشریات علمی, 4(1), pp. 7-14.
Owrangi, Bahareh, Habibagahi, Mojtaba, Hosseini, Ahmad, Fazelzadeh Haghighi, Negin, Mardani, Mohsen, Talei, Abdolrasoul, Ghaderi, Abbas, Jaberipour, Mansooreh. MDM2, E-cadherin, Survivin and Her2 mRNA Status in Peripheral Blood of Patients with Breast Cancer. سامانه مدیریت نشریات علمی, 1391; 4(1): 7-14.

MDM2, E-cadherin, Survivin and Her2 mRNA Status in Peripheral Blood of Patients with Breast Cancer

Middle East Journal of Cancer
مقاله 2، دوره 4، شماره 1، فروردین 2013، صفحه 7-14    اصل مقاله (381.02 K)
نوع مقاله: Original Article(s)
نویسندگان
Bahareh Owrangi1؛ Mojtaba Habibagahi2؛ Ahmad Hosseini1؛ Negin Fazelzadeh Haghighi1، 2؛ Mohsen Mardani1، 2؛ Abdolrasoul Talei1، 3؛ Abbas Ghaderi1، 2؛ Mansooreh Jaberipour* 1
1Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3Department of Surgery, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: MDM2, E-cadherin, survivin and Her2 genes are involved in the regulation of normal cell growth. However, any crucial change in their expression levels can convert a normal cell into a cancer cell. Numerous studies have identified alterations of these gene expression levels in various cancers, particularly in breast cancer. Thus, they may be used as diagnostic biomarkers. In this experiment, we aim to evaluate these gene transcripts in patients’ peripheral blood and compare the results with healthy individuals.Methods: RNA was extracted from peripheral blood cells of 52 breast cancer patients and 52 healthy volunteers. Then, cDNA was synthesized and assessed for MDM2, E-cadherin, and survivin and Her2 gene transcriptions in peripheral blood samples by quantitative real-time polymerase chain reaction.Results: There were no considerable differences in the expression of MDM2, E- cadherin, survivin and Her2 in cancer patients compared to healthy individuals. However, there were significantly correlation between E-cadherin, survivin and Her2 expression and some of the clinicopathological characteristics of patients studied. Also, survivin transcripts expression was positively correlated with Her2, E-cadherin, and MDM2 gene expressions.Conclusion: These results indicated no variations in MDM2, E-cadherin, Her2 and survivin gene expressions in patients compared to controls. We might not consider the examined biomarkers as valuable prognosis factors in primary breast cancer. However, additional research should be undertaken to assess these four genes in a larger sample size.
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