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Shiva, Atena, Zamanian, Ali, Arab, Shahin, Boloki, Mahsa. (1397). Immunohistochemical Study of p53 Expression in Patients with Erosive and Non-Erosive Oral Lichen Planus. سامانه مدیریت نشریات علمی, 19(2), 118-123. doi: 10.30476/dentjods.2018.41801
Atena Shiva; Ali Zamanian; Shahin Arab; Mahsa Boloki. "Immunohistochemical Study of p53 Expression in Patients with Erosive and Non-Erosive Oral Lichen Planus". سامانه مدیریت نشریات علمی, 19, 2, 1397, 118-123. doi: 10.30476/dentjods.2018.41801
Shiva, Atena, Zamanian, Ali, Arab, Shahin, Boloki, Mahsa. (1397). 'Immunohistochemical Study of p53 Expression in Patients with Erosive and Non-Erosive Oral Lichen Planus', سامانه مدیریت نشریات علمی, 19(2), pp. 118-123. doi: 10.30476/dentjods.2018.41801
Shiva, Atena, Zamanian, Ali, Arab, Shahin, Boloki, Mahsa. Immunohistochemical Study of p53 Expression in Patients with Erosive and Non-Erosive Oral Lichen Planus. سامانه مدیریت نشریات علمی, 1397; 19(2): 118-123. doi: 10.30476/dentjods.2018.41801

Immunohistochemical Study of p53 Expression in Patients with Erosive and Non-Erosive Oral Lichen Planus

Journal of Dentistry
مقاله 5، دوره 19، شماره 2، شهریور 2018، صفحه 118-123    اصل مقاله (253.39 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/dentjods.2018.41801
نویسندگان
Atena Shiva1؛ Ali Zamanian2؛ Shahin Arab* 3؛ Mahsa Boloki4
1Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran.
2Dept. of Restorative Dentistry, School of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran.
3Dept. of Clinical Biochemistry, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
4Dentist, School of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran.
چکیده
Statement of the Problem: Oral lichen planus is a common mucocutaneous lesion with a chronic inflammatory process mediated by immune factors while a few cases of the disease become malignant.Purpose: This study aimed to determine the frequency of p53 marker as a tumor suppressor in patients with erosive and non-erosive oral lichen planus (OLP) by using immunohistochemical methods.Materials and Method: This descriptive cross-sectional study investigated the p53 expression in 16 erosive OLP, 16 non-erosive OLP samples, and 8 samples of normal oral mucosa through immunohistochemistry. The percentage of stained cells in basal and suprabasal layers, and inflammatory infiltrate were graded according to the degree of staining; if 0%, <10%, 10-25%, and >50% of the cells were stained, they were considered as (-), (+), (++), (+++) and (++++), respectively. The obtained data was statistically analyzed and compared by using Chi square and Fisher’s exact test.Results: The mean percentage of p53 positive cells in erosive OLP (34.5±14.2) was considerably higher than that in non-erosive OLP (23.8±10.4) and normal mucosa (17.5±17). There was a significant difference among the three groups of erosive, non-erosive and control in terms of staining intensity. No significant difference existed between the patients’ age and sex in the two OLP groups.Conclusion: The increased incidence of p53 from normal mucosa to erosive OLP indicated the difference between biological behavior of erosive and non-erosive OLP. It can be claimed that the erosive OLP has great premalignant potential compared with the non-erosive one.
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