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Sugiura, Tsutomu, Yamamoto, Kazuhiko, Murakami, Kazuhiro, Horita, Satoshi, Matsusue, Yumiko, Nakashima, Chie, Kirita, Tadaaki. (1397). Immune Thrombocytopenic Purpura Detected with Oral Hemorrhage: a Case Report. سامانه مدیریت نشریات علمی, 19(2), 159-163. doi: 10.30476/dentjods.2018.41794
Tsutomu Sugiura; Kazuhiko Yamamoto; Kazuhiro Murakami; Satoshi Horita; Yumiko Matsusue; Chie Nakashima; Tadaaki Kirita. "Immune Thrombocytopenic Purpura Detected with Oral Hemorrhage: a Case Report". سامانه مدیریت نشریات علمی, 19, 2, 1397, 159-163. doi: 10.30476/dentjods.2018.41794
Sugiura, Tsutomu, Yamamoto, Kazuhiko, Murakami, Kazuhiro, Horita, Satoshi, Matsusue, Yumiko, Nakashima, Chie, Kirita, Tadaaki. (1397). 'Immune Thrombocytopenic Purpura Detected with Oral Hemorrhage: a Case Report', سامانه مدیریت نشریات علمی, 19(2), pp. 159-163. doi: 10.30476/dentjods.2018.41794
Sugiura, Tsutomu, Yamamoto, Kazuhiko, Murakami, Kazuhiro, Horita, Satoshi, Matsusue, Yumiko, Nakashima, Chie, Kirita, Tadaaki. Immune Thrombocytopenic Purpura Detected with Oral Hemorrhage: a Case Report. سامانه مدیریت نشریات علمی, 1397; 19(2): 159-163. doi: 10.30476/dentjods.2018.41794

Immune Thrombocytopenic Purpura Detected with Oral Hemorrhage: a Case Report

Journal of Dentistry
مقاله 11، دوره 19، شماره 2، شهریور 2018، صفحه 159-163    اصل مقاله (167.25 K)
نوع مقاله: Case Report
شناسه دیجیتال (DOI): 10.30476/dentjods.2018.41794
نویسندگان
Tsutomu Sugiura* 1؛ Kazuhiko Yamamoto2؛ Kazuhiro Murakami2؛ Satoshi Horita2؛ Yumiko Matsusue2؛ Chie Nakashima1؛ Tadaaki Kirita3
1Dept. of Oral and Maxillofacial Surgery, Nara Kasuga Hospital, Nara, Japan. Dept. of Oral and Maxillofacial Surgery, Nara Medical University, Nara, Japan.
2Dept. of Oral and Maxillofacial Surgery, Nara Medical University, Nara, Japan.
3Dept. of Oral and Maxillofacial Surgery, Nara Medical University, Nara, Japan.Japan
چکیده
Immune thrombocytopenic purpura (ITP) is an immune-mediated acquired disease found in both adults and children. It is characterized by transient or persistent decreases in the platelet count. We report a case of ITP detected based on oral hemorrhagic symptoms. The patient was a 79-year-old female with no significant past medical history. She presented with sudden onset of gingival bleeding and hemorrhagic bullae on the buccal mucosa. Gingival bleeding was difficult to control. Laboratory tests revealed severe thrombocytopenia with a platelet count as low as 2000/μL. Under a provisional diagnosis of a hematological disorder, she was referred to a hematologist. A peripheral smear showed normal-sized platelets. A bone marrow examination revealed increased numbers of megakaryocytes without morphologic abnormalities. The patient was diagnosed with ITP and treated with a combination of pulsed steroid therapy and high-dose immunoglobulin therapy. However, her severe thrombocytopenia was refractory to these treatments. Then, a thrombopoietin receptor agonist was begun as a second-line treatment. Her platelets rapidly increased, and no bleeding complications were reported. Because oral symptoms can be one of the initial manifestations of ITP, dentists should be familiar with the clinical appearance of ITP, and attention must be paid to detect and diagnose unidentified cases.
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