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Rezazadeh, Fahimeh, Ebrahimi, Rahele, Andisheh-Tadbir, Azadeh, Ashraf, Mohammad Javad, Khademi, Bijan. (1396). Evaluation of the Ki-67 and MCM3 Expression in Cytologic Smear of Oral Squamous Cell Carcinoma. سامانه مدیریت نشریات علمی, 18(3), 207-211.
Fahimeh Rezazadeh; Rahele Ebrahimi; Azadeh Andisheh-Tadbir; Mohammad Javad Ashraf; Bijan Khademi. "Evaluation of the Ki-67 and MCM3 Expression in Cytologic Smear of Oral Squamous Cell Carcinoma". سامانه مدیریت نشریات علمی, 18, 3, 1396, 207-211.
Rezazadeh, Fahimeh, Ebrahimi, Rahele, Andisheh-Tadbir, Azadeh, Ashraf, Mohammad Javad, Khademi, Bijan. (1396). 'Evaluation of the Ki-67 and MCM3 Expression in Cytologic Smear of Oral Squamous Cell Carcinoma', سامانه مدیریت نشریات علمی, 18(3), pp. 207-211.
Rezazadeh, Fahimeh, Ebrahimi, Rahele, Andisheh-Tadbir, Azadeh, Ashraf, Mohammad Javad, Khademi, Bijan. Evaluation of the Ki-67 and MCM3 Expression in Cytologic Smear of Oral Squamous Cell Carcinoma. سامانه مدیریت نشریات علمی, 1396; 18(3): 207-211.

Evaluation of the Ki-67 and MCM3 Expression in Cytologic Smear of Oral Squamous Cell Carcinoma

Journal of Dentistry
مقاله 8، دوره 18، شماره 3، آذر 2017، صفحه 207-211    اصل مقاله (345.67 K)
نوع مقاله: Original Article
نویسندگان
Fahimeh Rezazadeh1؛ Rahele Ebrahimi* 1؛ Azadeh Andisheh-Tadbir2؛ Mohammad Javad Ashraf3؛ Bijan Khademi4
1Dept. of Oral & Maxillofacial Medicine, School of Dentistry, Shahrekord University of Medical Sciences, Shahrekord, Iran.
2Oral and Dental Disease Research Center, Dept. of Oral & Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
3Dept. of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
4Otolaryngology Research Center, Dept. of Otorhinolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran.
چکیده
Statement of the Problem: Squamous cell carcinoma (SCC) is the most frequent oral cancer whose 5-year survival rate is 80% for early-detected lesions and nearly 30-50% for advanced lesions. Early detection of oral cancers and precancerous lesions can improve the patient’s survival and decrease the morbidity.Purpose: This study aimed to evaluate and compare the Ki-67 and MCM3 expression in cytologic smear of oral SCC (OSCC).Materials and Method: We examined 48 oral brush biopsies including 28 OSCC and 20 healthy non-smoking samples. Immunocytochemistry staining was performed for Ki-67 andMCM3 by using an EnVision-labeled peroxidase system, and labeling index (LI) was calculated.Results: Out of 28 OSCC cases, 27(96.4%) cases contained MCM3 positive cells and 22(78%) cases contained Ki-67 positive cells. All normal mucosa were Ki-67 and MCM3 negative. MCM3 and Ki-67 LI were significantly higher in OSCC than normal mucosa (p< 0.001). MCM3 LI was significantly higher than Ki-67 LI in OSCC group (p< 0.001).Conclusion: Immunocytologic evaluation of Ki-67 and MCM3 can be used for early detection of OSCC. Furthermore, MCM3 may be a more sensitive cytologic biomarker than Ki-67 in SCC patients. Keywords ● Squamous Cell Carcinoma  ● Cytology  ● Biopsy  ● Ki-67 antigen  ● Minichromosome Maintenance Complex Component 3
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