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Valibeigi, Behnaz, Ashraf, Mohamad Javad, Kerdegari, Narges, Safai, Akbar, Abedi, Elham, Khademi, Bijan, Azarpira, Negar. (1396). Prevalence of Human Papilloma Virus in Sinonasal Papilloma in Southern Iranian Population. سامانه مدیریت نشریات علمی, 18(2), 143-148.
Behnaz Valibeigi; Mohamad Javad Ashraf; Narges Kerdegari; Akbar Safai; Elham Abedi; Bijan Khademi; Negar Azarpira. "Prevalence of Human Papilloma Virus in Sinonasal Papilloma in Southern Iranian Population". سامانه مدیریت نشریات علمی, 18, 2, 1396, 143-148.
Valibeigi, Behnaz, Ashraf, Mohamad Javad, Kerdegari, Narges, Safai, Akbar, Abedi, Elham, Khademi, Bijan, Azarpira, Negar. (1396). 'Prevalence of Human Papilloma Virus in Sinonasal Papilloma in Southern Iranian Population', سامانه مدیریت نشریات علمی, 18(2), pp. 143-148.
Valibeigi, Behnaz, Ashraf, Mohamad Javad, Kerdegari, Narges, Safai, Akbar, Abedi, Elham, Khademi, Bijan, Azarpira, Negar. Prevalence of Human Papilloma Virus in Sinonasal Papilloma in Southern Iranian Population. سامانه مدیریت نشریات علمی, 1396; 18(2): 143-148.

Prevalence of Human Papilloma Virus in Sinonasal Papilloma in Southern Iranian Population

Journal of Dentistry
مقاله 10، دوره 18، شماره 2، شهریور 2017، صفحه 143-148    اصل مقاله (446.91 K)
نوع مقاله: Original Article
نویسندگان
Behnaz Valibeigi1؛ Mohamad Javad Ashraf1؛ Narges Kerdegari1؛ Akbar Safai1؛ Elham Abedi1؛ Bijan Khademi2؛ Negar Azarpira* 3
1Dept. of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran.
2Dept. of Otolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran.
3Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
چکیده
Statement of the Problem: Sinonasal papilloma (SNP) is a rare benign lesion characterized by high recurrence rate and malignant transformation. Purpose: This study aimed to investigate the prevalence of human papilloma virus (HPV) infection in these lesions in South of Iran. Materials and Method: In this cross sectional retrospective study, a total of 41 patients, 38 SNP and 3 SNP/Squamous cell carcinoma cases, from 2007 to 2014 were studied. Human papilloma virus (HPV) DNA detection was performed by nested PCR method and positive cases were analyzed for high risk HPV-16 and HPV-18. Results: HPV was detected in 31.7%; HPV- 16 in 4.9% and HPV 18 was not detected at all. Dysplastic epithelium was detected in 53% that was not associated with HPV. Three cases were accompanied with malignant transformation that HPV genome was detected in only one case and none of them were positive for HPV16 /18 genomic DNA. Conclusion: Current research suggests that HPV may be involved in the development of SNP. But the high risk HPV is not important in malignant transformation. More studies are needed to elucidate the possible etiologic mechanism between HPV, inverted papilloma, and squamous cell carcinoma. Keywords ● Sinonasal ● Papilloma ● Carcinoma ● Human papilloma virus ● High risk
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