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Topical Olive Leaf Extract Improves Healing of Oral Mucositis in Golden Hamsters | ||
| Journal of Dentistry | ||
| مقاله 6، دوره 17، شماره 4، اسفند 2016، صفحه 335-342 اصل مقاله (1.91 M) | ||
| نوع مقاله: Original Article | ||
| نویسندگان | ||
| Najmeh Showraki1؛ Maryam Mardani2؛ Masoumeh Emamghoreishi3؛ Azadeh Andishe-Tadbir4؛ Alireza Aram5؛ Peiman Mehriar6؛ Mahmoud Omidi7؛ Masood Sepehrimanesh8؛ Omid Koohi-Hosseinabadi9؛ Nader Tanideh* 10 | ||
| 1Post Graduate Student, Dept. of Oral Medicine, School of Dentistry, Shiraz University of Medical sciences, Shiraz, Iran. | ||
| 2Dept. of Oral Medicine, School of Dentistry, Shiraz University of Medical sciences, Shiraz, Iran. | ||
| 3Dept. of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 4Dept. of Oral and Maxillofacial Pathology, Prevention and Treatment of Oral and Dental Diseases Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 5Transgenic Technologies Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 6School of Dentistry, University of Southern California, Los Angeles, USA. | ||
| 7Dept. of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 8Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 9Laboratory Animals Center, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 10Dept. of Pharmacology, School of Medicine, Transgenic Technologies Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| چکیده | ||
| Statement of the Problem: Oral mucositis (OM) is a common side effect of anti-cancer drugs and needs significant attention for its prevention.Purpose: This study aimed to evaluate the healing effects of olive leaf extract on 5-fluorouracil-induced OM in golden hamster.Materials and Method: OM was induced in 63 male golden hamsters by the combination of 5-fluorouracil injections (days 0, 5 and 10) and the abrasion of the cheek pouch (days 3 and 4). On day 12, hamsters were received topical olive leaf extract ointment, base of ointment, or no treatment (control) for 5 days. Histopathology evaluations, blood examinations, and tissue malondialdehyde level measurement were performed 1, 3 and 5 days after treatments.Results: Histopathology score and tissue malondialdehyde level were significantly lower in olive leaf extract treated group in comparison with control and base groups (p= 0.000). Significant decreases in white blood cell, hemoglobin, hematocrit , and mean corpuscular volume and an increase in mean corpuscular hemoglobin concentration were observed in olive leaf extract treated group in comparison with control and base groups (p< 0.05).Conclusion: Our findings demonstrated that daily application of olive leaf extract ointment had healing effect on 5-fluorouracil induced OM in hamsters. Moreover, the beneficial effect of olive leaf extract on OM might be due to its antioxidant and anti-inflammatory properties.Keywords ● 5- fluorouracil ● Anti-inflammatory ● Antioxidant ● Olive Leaf ● Oral Mucositis | ||
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