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Amirchaghmaghi, Maryam, Hashemy, Seyed Isaac, Alirezaei, Banafsheh, Jahed Keyhani, Fereshteh, Kargozar, Sanaz, Vasigh, Samaneh, Gharaei, Shideh, Pakfetrat, Atessa. (1394). Evaluation of Plasma Isoprostane in Patients with Oral Lichen Planus. سامانه مدیریت نشریات علمی, 17(1), 21-25.
Maryam Amirchaghmaghi; Seyed Isaac Hashemy; Banafsheh Alirezaei; Fereshteh Jahed Keyhani; Sanaz Kargozar; Samaneh Vasigh; Shideh Gharaei; Atessa Pakfetrat. "Evaluation of Plasma Isoprostane in Patients with Oral Lichen Planus". سامانه مدیریت نشریات علمی, 17, 1, 1394, 21-25.
Amirchaghmaghi, Maryam, Hashemy, Seyed Isaac, Alirezaei, Banafsheh, Jahed Keyhani, Fereshteh, Kargozar, Sanaz, Vasigh, Samaneh, Gharaei, Shideh, Pakfetrat, Atessa. (1394). 'Evaluation of Plasma Isoprostane in Patients with Oral Lichen Planus', سامانه مدیریت نشریات علمی, 17(1), pp. 21-25.
Amirchaghmaghi, Maryam, Hashemy, Seyed Isaac, Alirezaei, Banafsheh, Jahed Keyhani, Fereshteh, Kargozar, Sanaz, Vasigh, Samaneh, Gharaei, Shideh, Pakfetrat, Atessa. Evaluation of Plasma Isoprostane in Patients with Oral Lichen Planus. سامانه مدیریت نشریات علمی, 1394; 17(1): 21-25.

Evaluation of Plasma Isoprostane in Patients with Oral Lichen Planus

Journal of Dentistry
مقاله 4، دوره 17، شماره 1، خرداد 2016، صفحه 21-25    اصل مقاله (70.31 K)
نوع مقاله: Original Articles
نویسندگان
Maryam Amirchaghmaghi1؛ Seyed Isaac Hashemy* 2؛ Banafsheh Alirezaei3؛ Fereshteh Jahed Keyhani3؛ Sanaz Kargozar3؛ Samaneh Vasigh3؛ Shideh Gharaei4؛ Atessa Pakfetrat1
1Oral and Maxillofacial Diseases Research Center, Dept. of Oral Medicine, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
2Surgical Oncology Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of MedicalSciences, Mashhad, Iran.
3Undergraduate Student, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
4Undergraduate Student, Faculty of Dentistry, Mashhad University of MedicalSciences, Mashhad, Iran.
چکیده
Statement of the Problems: Lichen planus is a chronic inflammatory disease. Free radicals and reactive oxygen species play important roles in pathogenesis of oral lichen planus (OLP). Isoprostanes show oxidative stress and are formed by free-radical mediated lipid peroxidation of arachidonic acid and cell membrane phospholipids.Purpose: This study was conducted to evaluate the plasma level of 8-isoprostane in patients suffering from erosive and non-erosive forms of OLP.Materials and Method: In this case-control study, 31 patients with OLP and 30 control subjects were enrolled. Plasma samples were obtained and the level of 8-isoprostane was measured with Sandwich enzyme-linked immunosorbent assay (ELISA) in both groups. The data were analyzed by using two-sample t-test, chi-square and ANOVA tests.Results: The results showed significant increase in the plasma level of 8-isoprostane in OLP group compared with the control group. The results of independent t-test revealed no significant correlation between the plasma level of isoprostane and sex, smoking, or previous treatment.Conclusion: Based on the findings of this study, oxidative stress was increased in patients with OLP, reflected by higher concentrations of 8-isoprostane in plasma.Key Words: Oral Lichen Planus; Isoprostane; Oxidative Stress
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