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Head and Neck Posttransplant Lymphoproliferative Disorders (PTLD): A Literature Review | ||
| Journal of Dentistry | ||
| مقاله 3، دوره 6، Issue 1, 2، شهریور 2005، صفحه 18-25 اصل مقاله (208.5 K) | ||
| نوع مقاله: Original Article | ||
| نویسندگان | ||
| G. Rezvani* 1؛ A. Dehghani Najvani2؛ M. Motamedi2 | ||
| 1Assistant Professor, Department of Pathology, School of Dentistry, Shiraz University of Medical Sciences | ||
| 2Student | ||
| چکیده | ||
| Nowadays transplantation is widely used to manage end organ failure, the way that saves patient's lives and increases their survival rate. But it has some complications such as posttransplant malignancies; one of them is posttransplant lymphoproliferative disorder (PTLD). PTLD is more prevalent in children than in adults and it occurs from months to years after transplantation with the peak of 3-7 months. The incidence of PTLD after heart-lung transplantation is the most (9.4%) and after kidney transplantation is the least (1%). The common sites of PTLD involvement include abdominal region (32%), bone marrow (25%) and other sites including head and neck (43%). PTLD is related with immunosuppression caused by administration of immunosuppressive agents and is mostly accompanied by the proliferation of Epstein-Barr virus. Clinical presentation of PTLD varies from a self limiting mononucleosis to a generalized lymphoid infiltration or even a lymphoma. Management of PTLD includes reduction of immunosuppression, using anti CD20 antibody, antiviral drugs, chemothrapy and radiotherapy which are not so efficient. It's prognosis is poor and has 54% mortality rate. Clinical features of PTLD in head and neck region are cervical lymphadenopathy, generalized gingival hyperplasia with erythema, swelling, cyanotic foci and chronic mucosal ulcers; so this neccessitizes referring of a patient with such signs and symptoms or other suspicious conditions in the head and neck to a dentist for early diagnosis and biopsy. This article reviews PTLD with emphasis on oral manifestations and head and neck involvement. Key words: Lymphoproliferative Disorders, Transplantation | ||
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