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Saghafi, Sh., Amoueian, S., ZareMahmoodAbadi, R., Salehinejad, J., Shahabnia, AA.. (1389). p53 and Bcl-2 Expression in Oral Verrucous Carcinoma and Squamous Cell Carcinoma. سامانه مدیریت نشریات علمی, 11(4), 268-274.
Sh. Saghafi; S. Amoueian; R. ZareMahmoodAbadi; J. Salehinejad; AA. Shahabnia. "p53 and Bcl-2 Expression in Oral Verrucous Carcinoma and Squamous Cell Carcinoma". سامانه مدیریت نشریات علمی, 11, 4, 1389, 268-274.
Saghafi, Sh., Amoueian, S., ZareMahmoodAbadi, R., Salehinejad, J., Shahabnia, AA.. (1389). 'p53 and Bcl-2 Expression in Oral Verrucous Carcinoma and Squamous Cell Carcinoma', سامانه مدیریت نشریات علمی, 11(4), pp. 268-274.
Saghafi, Sh., Amoueian, S., ZareMahmoodAbadi, R., Salehinejad, J., Shahabnia, AA.. p53 and Bcl-2 Expression in Oral Verrucous Carcinoma and Squamous Cell Carcinoma. سامانه مدیریت نشریات علمی, 1389; 11(4): 268-274.

p53 and Bcl-2 Expression in Oral Verrucous Carcinoma and Squamous Cell Carcinoma

Journal of Dentistry
مقاله 1، دوره 11، شماره 4، اسفند 2010، صفحه 268-274    اصل مقاله (211.44 K)
نوع مقاله: Original Article
نویسندگان
Sh. Saghafi* 1؛ S. Amoueian2؛ R. ZareMahmoodAbadi1؛ J. Salehinejad1؛ AA. Shahabnia3
1Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Dental Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
2Dept. of Pathology, Emam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
3Dentist, Private Practice
چکیده
Statement of Problem: Verrucous carcinoma (VC) is a rare type of squamous cell carcinoma (SCC). These two lesions have many biological and clinical differences and proper diagnosis of these tumors has a great influence on the patient's treatment.Purpose: The purpose of this study was to compare the expression of p53 and Bcl-2 in VC, SCC and pseudoepitheliamatos hyperplasia (PEH).Methods and Material: In this study, expressions of p53 and Bcl-2 markers in 20 samples  of  paraffin blocks of VC, 23 samples of SCC, and 22 samples of PEH were examined by immunohistochemistry method. Immunoreactiv-ity was diagnosed for p53 in the nucleus and for Bcl-2 in the cytoplasm of cells. Then, the mean percentage of the expression of p53 and Bcl-2 was compared. The collected data were analyzed, using SPSS Ver. 7.5. For statistical analysis, ANOVA and Tukey tests were used for Bcl-2, and Kruskal-Wallis was used for comparison of the markers.Result: There was a significant difference in the mean of Bcl-2 expression between the lesions which the VC was significantly lower than the others.There was also a significant difference in the mean of p53 expression between the lesions.Conclusion: p53 and Bcl-2 are two immunohistochemical markers which can be helpful in differential diagnosis of VC and SCC. Key words: Verrucous carcinoma, Squamous cell carcinoma, Psudoepithliomatous hyperplasia, Immunohistochemistry, p53, Bcl-2
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