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Andisheh Tadbir, A., Ashraf, MJ., Ketabi, MA.. (1388). The Modified AgNOR Staining in Diagnosis of Benign and Malignant Salivary Gland Tumors. سامانه مدیریت نشریات علمی, 10(4), 322-329.
A. Andisheh Tadbir; MJ. Ashraf; MA. Ketabi. "The Modified AgNOR Staining in Diagnosis of Benign and Malignant Salivary Gland Tumors". سامانه مدیریت نشریات علمی, 10, 4, 1388, 322-329.
Andisheh Tadbir, A., Ashraf, MJ., Ketabi, MA.. (1388). 'The Modified AgNOR Staining in Diagnosis of Benign and Malignant Salivary Gland Tumors', سامانه مدیریت نشریات علمی, 10(4), pp. 322-329.
Andisheh Tadbir, A., Ashraf, MJ., Ketabi, MA.. The Modified AgNOR Staining in Diagnosis of Benign and Malignant Salivary Gland Tumors. سامانه مدیریت نشریات علمی, 1388; 10(4): 322-329.

The Modified AgNOR Staining in Diagnosis of Benign and Malignant Salivary Gland Tumors

Journal of Dentistry
مقاله 8، دوره 10، شماره 4، اسفند 2009، صفحه 322-329    اصل مقاله (191.27 K)
نوع مقاله: Original Article
نویسندگان
A. Andisheh Tadbir* 1؛ MJ. Ashraf2؛ MA. Ketabi3
1Dept. of Oral and Maxillofacial Pathology, Faculty of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
2Dept. of Pathology, Khalili Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
3Dental Student, Faculty of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
چکیده
Statement of problem: Salivary gland neoplasms show varied histological and biological characteristics, and there may be difficulty in differentiating between low grade malignancies and benign tumors of the salivary glands.Purpose: The aim of this study was to investigate the diagnostic value of modified AgNOR technique in distinguishing between benign and malignant salivary gland tumors.Materials and Method: In this cross-sectional study, 40 benign salivary gland tumors (34 pleomorphic adenoma, 6 warthin tumor), 40 malignant neoplasms (26 adenoid cystic carcinoma, 14 mucoepidermoid carcinoma) and 10 chronic sialadenitis were stained with modified AgNOR technique. AgNOR counts, variation in size and dispersion of AgNOR dots in the cells were graded and compared in benign and malignant tumors. The data were statistically analyzed by ANOVA, Tukey, t-test and Kruskal-Wallis tests.Results: The mean AgNOR counts for the benign neoplasms (1.29±0.13) were less than those for the malignant neoplasms (2.87±0.25). Variation in AgNOR size and dispersion was of a higher grade in malignancy when compared with benign neoplasms ( p <0.05).Conclusion: Our results suggest that modified AgNOR staining is useful for distinguishing benign from malignant tumors, but variation in AgNOR size and dispersion in addition to the count should also be considered.Key words: Modified AgNOR, Pleomorphic adenoma, Warthin tumor, Adenoid cystic carcinoma, Mucoepidermoid carcinoma
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