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Evaluation of the Possible Synergic Regenerative Effects of Platelet-Rich Plasma and Hydroxyapatite/Zirconia in the Rabbit Mandible Defect Model | ||
| Iranian Journal of Medical Sciences | ||
| مقاله 8، دوره 43، شماره 6، بهمن 2018، صفحه 633-644 اصل مقاله (3.18 M) | ||
| نوع مقاله: Original Article(s) | ||
| شناسه دیجیتال (DOI): 10.30476/ijms.2018.40587 | ||
| نویسندگان | ||
| Sheila Shahsavari-Pour1؛ Ehsan Aliabadi1؛ Mona Latifi2؛ Nehle Zareifard3؛ Mohammad Reza Namavar4؛ Tahereh Talaei-Khozani* 5 | ||
| 1Department of Oral and Maxillofacial Surgery, School of Dentistry, Shiraz University of Medical Sciences, Shiraz Iran | ||
| 2Department of Tissue Engineering, National Institute of Genetic Engineering and Biotechnology, Iran | ||
| 3Stem Cell Lab, Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 4Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 5Tissue Engineering Lab, Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| چکیده | ||
| Background: Platelet-rich plasma (PRP) and bioceramics such as hydroxyapatite (HA) and zirconium oxide (ZrO2) are used to reconstruct mandibular defects. We sought to determine the synergistic effects of HA/ZrO2 and PRP and compare their osteogenic activity.Methods: ZrO2 scaffolds were constructed by the slurry method and were then coated with HA and impregnated by PRP/heparan sulfate (HS). Bilateral mandibular defects were created in 26 male rabbits. In 20 rabbits, the left defects were treated with HA/ZrO2/PRP (Group 1) and the corresponding right defects were filled with HA/ZrO2 (Group 2). The 6 remaining models were treated with PRP gels at both sides (Group 3). The osteoconductivity of HA/ZrO2/PRP was compared with that of HA/ZrO2 or PRP by radiological and histological methods after the follow-up period, at weeks 6, 8, and 12. The statistical analyses were performed by ANOVA and LSD using SPSS, version 16.0, for Windows (P<0.05).Results: After 2 weeks, the percentage of the surface occupied by bone was significantly higher in the HA/ZrO2/PRP-treated defects than in the PRP-treated defects (P=0.007). Osteoblast and osteocyte counts were higher significantly in the PRP-treated group (P=0.032); however, the cells had not started matrix formation on a large scale and just small islands of osteoid with trapped osteocytes were observed. In the long term, the regenerative potential of all the scaffolds was the same. Conclusion: HA/ZrO2 showed a superior osteoconductive capacity over PRP in the short term; however, they showed no long-term synergic effects. | ||
| کلیدواژه‌ها | ||
| Durapatite؛ Hydroxyapatite؛ Zirconium oxide؛ Platelet-Rich plasma؛ Heparan sulfate proteoglycans؛ Osteogenesis | ||
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