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Afzal, Ehsan, Alinezhad, Sedigheh, Khorsand, Marjan, Khoshnood, Mohammad Javad, Takhshid, Mohammad Ali. (1397). Effects of Two-by-Two Combination Therapy with Valproic Acid, Lithium Chloride, and Celecoxib on the Angiogenesis of the Chicken Chorioallantoic Membrane. سامانه مدیریت نشریات علمی, 43(5), 506-513. doi: 10.30476/ijms.2018.40571
Ehsan Afzal; Sedigheh Alinezhad; Marjan Khorsand; Mohammad Javad Khoshnood; Mohammad Ali Takhshid. "Effects of Two-by-Two Combination Therapy with Valproic Acid, Lithium Chloride, and Celecoxib on the Angiogenesis of the Chicken Chorioallantoic Membrane". سامانه مدیریت نشریات علمی, 43, 5, 1397, 506-513. doi: 10.30476/ijms.2018.40571
Afzal, Ehsan, Alinezhad, Sedigheh, Khorsand, Marjan, Khoshnood, Mohammad Javad, Takhshid, Mohammad Ali. (1397). 'Effects of Two-by-Two Combination Therapy with Valproic Acid, Lithium Chloride, and Celecoxib on the Angiogenesis of the Chicken Chorioallantoic Membrane', سامانه مدیریت نشریات علمی, 43(5), pp. 506-513. doi: 10.30476/ijms.2018.40571
Afzal, Ehsan, Alinezhad, Sedigheh, Khorsand, Marjan, Khoshnood, Mohammad Javad, Takhshid, Mohammad Ali. Effects of Two-by-Two Combination Therapy with Valproic Acid, Lithium Chloride, and Celecoxib on the Angiogenesis of the Chicken Chorioallantoic Membrane. سامانه مدیریت نشریات علمی, 1397; 43(5): 506-513. doi: 10.30476/ijms.2018.40571

Effects of Two-by-Two Combination Therapy with Valproic Acid, Lithium Chloride, and Celecoxib on the Angiogenesis of the Chicken Chorioallantoic Membrane

Iranian Journal of Medical Sciences
مقاله 7، دوره 43، شماره 5، آذر 2018، صفحه 506-513    اصل مقاله (1.96 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2018.40571
نویسندگان
Ehsan Afzal1؛ Sedigheh Alinezhad1؛ Marjan Khorsand1؛ Mohammad Javad Khoshnood2؛ Mohammad Ali Takhshid*
1Diagnostic Laboratory Sciences and Technology Research Center, Paramedical School, Shiraz University of Medical Sciences, Shiraz, Iran
2School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: The synergistic effects of valproic acid (VPA), lithium (Li), and celecoxib (CX) have been shown in combination therapy against the proliferation and metastasis of numerous cancers. Angiogenesis plays a critical role in the pathogenesis of tumor growth and metastasis. The aim of the present study was to evaluate the antiangiogenic effects of VPA, lithium chloride (LiCl), and CX, alone or in 2-by-2 combinations, using the chicken chorioallantoic membrane (CAM) assay.Methods: Fertilized chicken eggs were randomly divided into 10 groups: control, VPA (1.8 and 3.6 µmol/CAM), Li (0.15 and 0.60 µmol/CAM), CX (0.02 and 0.08 µmol/CAM), VPA+Li, VPA+CX, and CX+Li (n=10 per group). A window was made on the eggshells and the CAMs were exposed to a filter disk containing VPA, LiCl, and CX, alone or in 2-by-2 combinations. The control CAMs were treated with distilled water (vehicle). Three days after the treatment, the number of vessel branch points was counted in each CAM. The data were analyzed using SPSS, version 15.One-way ANOVA, followed by the Tukey tests, was used to compare the groups. A P
کلیدواژه‌ها
Angiogenesis inhibitors؛ Combined modality therapy؛ Valproic acid؛ Celecoxib؛ Lithium chloride
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