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Bakhtiarpoor, Maryam, Setorki, Mahbubeh, Kaffashian, Mohammad Reza. (1397). Effects of Essential Oil of Satureja Bachtiarica Bunge in a Rat Model of Reserpine-Induced Depression. سامانه مدیریت نشریات علمی, 43(4), 409-415. doi: 10.30476/ijms.2018.40558
Maryam Bakhtiarpoor; Mahbubeh Setorki; Mohammad Reza Kaffashian. "Effects of Essential Oil of Satureja Bachtiarica Bunge in a Rat Model of Reserpine-Induced Depression". سامانه مدیریت نشریات علمی, 43, 4, 1397, 409-415. doi: 10.30476/ijms.2018.40558
Bakhtiarpoor, Maryam, Setorki, Mahbubeh, Kaffashian, Mohammad Reza. (1397). 'Effects of Essential Oil of Satureja Bachtiarica Bunge in a Rat Model of Reserpine-Induced Depression', سامانه مدیریت نشریات علمی, 43(4), pp. 409-415. doi: 10.30476/ijms.2018.40558
Bakhtiarpoor, Maryam, Setorki, Mahbubeh, Kaffashian, Mohammad Reza. Effects of Essential Oil of Satureja Bachtiarica Bunge in a Rat Model of Reserpine-Induced Depression. سامانه مدیریت نشریات علمی, 1397; 43(4): 409-415. doi: 10.30476/ijms.2018.40558

Effects of Essential Oil of Satureja Bachtiarica Bunge in a Rat Model of Reserpine-Induced Depression

Iranian Journal of Medical Sciences
مقاله 9، دوره 43، شماره 4، مهر 2018، صفحه 409-415    اصل مقاله (537.24 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2018.40558
نویسندگان
Maryam Bakhtiarpoor1؛ Mahbubeh Setorki* 1؛ Mohammad Reza Kaffashian2
1Department of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran
2Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran
چکیده
Background: Due to the unfavorable side effects of some commonly used chemical drugs, the trend in the public has shifted towards using herbal medicines to treat central nervous system disorders like depression. The present experimental study was designed to evaluate the effect of Marze (Satureja bachtiarica Bunge) essential oil on reserpine-induced depression in rats. Methods: In total, 48 male Wistar rats were randomly divided into 6 groups: 1) control, 2) reserpine, 3-5) reserpine with 50, 75 and 100 mg/kg of Marze essential oil, respectively, and 6) reserpine and fluoxetine. The forced swimming test was used to evaluate the antidepressant activity of the essential oil. Total antioxidant capacity (TAC) and MDA levels of serum and brain were also determined.Results: Reserpine induced a significant increase in the immobility time of rats in the forced swimming test (P=0.02) and treatment with Marze essential oil (50, 100 mg/kg) ameliorated the reserpine induced changes (P=0.04, P=0.03, respectively). Reserpine-induced reduction in brain TCA was improved using Marze essential oil at a dose of 100 mg/kg (P=0.04). Marze essential oil at 100 mg/kg dose significantly decreased the MDA level in the brain tissues of reserpine-treated rats (P=0.04). Conclusion: Marze (Satureja bachtiarica Bunge) essential oil has the ability to prevent depression induced by reserpine probably via its antioxidant activity.
کلیدواژه‌ها
Satureja Bachtiarica Bunge؛ Marze؛ Antidepressant Activity؛ Antioxidant Activity؛ Forced Swim Test
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