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Talebi, Roghayeh, Saki, Nasrin, Raeisi Shahraki, Hadi, Owji, Seyed Hossein. (1397). An Epidemiological Study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis during 2010-2015 at Shahid Faghihi Hospital, Shiraz, Iran. سامانه مدیریت نشریات علمی, 43(4), 421-425. doi: 10.30476/ijms.2018.40552
Roghayeh Talebi; Nasrin Saki; Hadi Raeisi Shahraki; Seyed Hossein Owji. "An Epidemiological Study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis during 2010-2015 at Shahid Faghihi Hospital, Shiraz, Iran". سامانه مدیریت نشریات علمی, 43, 4, 1397, 421-425. doi: 10.30476/ijms.2018.40552
Talebi, Roghayeh, Saki, Nasrin, Raeisi Shahraki, Hadi, Owji, Seyed Hossein. (1397). 'An Epidemiological Study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis during 2010-2015 at Shahid Faghihi Hospital, Shiraz, Iran', سامانه مدیریت نشریات علمی, 43(4), pp. 421-425. doi: 10.30476/ijms.2018.40552
Talebi, Roghayeh, Saki, Nasrin, Raeisi Shahraki, Hadi, Owji, Seyed Hossein. An Epidemiological Study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis during 2010-2015 at Shahid Faghihi Hospital, Shiraz, Iran. سامانه مدیریت نشریات علمی, 1397; 43(4): 421-425. doi: 10.30476/ijms.2018.40552

An Epidemiological Study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis during 2010-2015 at Shahid Faghihi Hospital, Shiraz, Iran

Iranian Journal of Medical Sciences
مقاله 11، دوره 43، شماره 4، مهر 2018، صفحه 421-425    اصل مقاله (190.95 K)
نوع مقاله: Brief Report(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2018.40552
نویسندگان
Roghayeh Talebi1؛ Nasrin Saki2؛ Hadi Raeisi Shahraki3؛ Seyed Hossein Owji* 1
1Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Dermatology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; and Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3Department of Biostatistics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
The Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two ends of the spectrum of severe immunobullous state characterized by keratinocyte apoptosis. The present study aimed to draw attention to various epidemiological features of SJS and TEN diseases such as causative drugs, underlying diseases, duration of hospitalization, and types of treatment. The records of all patients with the diagnosis of SJS, TEN, and SJS/TEN overlap during 2010-2015 were retrospectively reviewed. The records belonged to patients who were admitted to the Dermatology Tertiary Referral Center of Shahid Faghihi Hospital affiliated to the Shiraz University of Medical Sciences, Shiraz, Iran.From a total of 97 patients with such skin disorders, we identified SJS in 89 (91.8 %), TEN in 5 (5.1%), and SJS/TEN overlap in 3 (3.1%) patients. The most commonly consumed drug was Lamotrigine (21.6%) and the most common drug category was anticonvulsants (46.4%). In line with many studies, especially in Iran, Lamotrigine and anticonvulsant drugs were the most common causative drug and epilepsy was the most common underlying disease. Patients with SJS/TEN overlap or TEN were treated with combination therapy, whereas SJS patients received systemic corticosteroids.
کلیدواژه‌ها
Stevens-Johnson syndrome؛ Drug eruptions؛ Epidemiology؛ Iran
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