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Mortazavi, Hossein, Izadi Firouzabadi, Leila, Ghanadan, Alireza, Seirafi, Hassan, Emadi, Seyed Naser, Shakoei, Safoura. (1397). Occurrence of Mycosis Fungoides in an Iranian Chemical Victim of the Iran–Iraq War with a Long-term Follow-Up: A Case Report and Review of Literature. سامانه مدیریت نشریات علمی, 43(3), 324-327. doi: 10.30476/ijms.2018.40529
Hossein Mortazavi; Leila Izadi Firouzabadi; Alireza Ghanadan; Hassan Seirafi; Seyed Naser Emadi; Safoura Shakoei. "Occurrence of Mycosis Fungoides in an Iranian Chemical Victim of the Iran–Iraq War with a Long-term Follow-Up: A Case Report and Review of Literature". سامانه مدیریت نشریات علمی, 43, 3, 1397, 324-327. doi: 10.30476/ijms.2018.40529
Mortazavi, Hossein, Izadi Firouzabadi, Leila, Ghanadan, Alireza, Seirafi, Hassan, Emadi, Seyed Naser, Shakoei, Safoura. (1397). 'Occurrence of Mycosis Fungoides in an Iranian Chemical Victim of the Iran–Iraq War with a Long-term Follow-Up: A Case Report and Review of Literature', سامانه مدیریت نشریات علمی, 43(3), pp. 324-327. doi: 10.30476/ijms.2018.40529
Mortazavi, Hossein, Izadi Firouzabadi, Leila, Ghanadan, Alireza, Seirafi, Hassan, Emadi, Seyed Naser, Shakoei, Safoura. Occurrence of Mycosis Fungoides in an Iranian Chemical Victim of the Iran–Iraq War with a Long-term Follow-Up: A Case Report and Review of Literature. سامانه مدیریت نشریات علمی, 1397; 43(3): 324-327. doi: 10.30476/ijms.2018.40529

Occurrence of Mycosis Fungoides in an Iranian Chemical Victim of the Iran–Iraq War with a Long-term Follow-Up: A Case Report and Review of Literature

Iranian Journal of Medical Sciences
مقاله 11، دوره 43، شماره 3، مرداد 2018، صفحه 324-327    اصل مقاله (1.49 M)
نوع مقاله: Case Report(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2018.40529
نویسندگان
Hossein Mortazavi1؛ Leila Izadi Firouzabadi1؛ Alireza Ghanadan2؛ Hassan Seirafi1؛ Seyed Naser Emadi1؛ Safoura Shakoei* 3
1Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran
2Department of Pathology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran
3Department of Dermatology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma. Persistent antigenic stimulation has been claimed to play a role in the development of this malignancy. We aimed to show the role of sulfur mustard in the pathogenesis of MF. A 45-year-old man with MF is introduced herein. He was a victim of chemical exposure in 1987 during the Iran–Iraq war. He developed skin lesions 3 years after exposure to sulfur mustard gas at the age of 21. Seven years after his exposure to sulfur mustard gas, a biopsy from the posterior distal part of his calf, which was injured and had bulla, revealed MF. Later, he developed more lesions on his extremities, trunk, and abdomen. On his previous admission, his left eyebrow was involved. A punch biopsy specimen was obtained from his eyebrow lesion, which rendered diffuse infiltration of atypical lymphocyte cells with some convoluted nuclei and scant cytoplasm admixed with lymphocytes, histiocytes, and mast cells compatible with the nodular stage of MF. At his last admission, a biopsy was obtained from the plaque lesions on his left thigh, and a TCR-γ gene rearrangement of the paraffin block of the plaque lesions revealed positive monoclonality. All the findings supported the MF diagnosis. We concluded that sulfur mustard could be a risk factor for MF development.
کلیدواژه‌ها
Mycosis fungoides؛ Lymphoma, T-Cell, Cutaneous؛ Environmental exposure؛ Sulfur mustard
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