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Keshavarz, Mojtaba, Yekzaman, Behdad. (1396). Amelioration of Pentylenetetrazole-Induced Seizures by Modulators of Sigma, N-Methyl-D-Aspartate, and Ryanodine Receptors in Mice. سامانه مدیریت نشریات علمی, 43(2), 195-201. doi: 10.30476/ijms.2018.40528
Mojtaba Keshavarz; Behdad Yekzaman. "Amelioration of Pentylenetetrazole-Induced Seizures by Modulators of Sigma, N-Methyl-D-Aspartate, and Ryanodine Receptors in Mice". سامانه مدیریت نشریات علمی, 43, 2, 1396, 195-201. doi: 10.30476/ijms.2018.40528
Keshavarz, Mojtaba, Yekzaman, Behdad. (1396). 'Amelioration of Pentylenetetrazole-Induced Seizures by Modulators of Sigma, N-Methyl-D-Aspartate, and Ryanodine Receptors in Mice', سامانه مدیریت نشریات علمی, 43(2), pp. 195-201. doi: 10.30476/ijms.2018.40528
Keshavarz, Mojtaba, Yekzaman, Behdad. Amelioration of Pentylenetetrazole-Induced Seizures by Modulators of Sigma, N-Methyl-D-Aspartate, and Ryanodine Receptors in Mice. سامانه مدیریت نشریات علمی, 1396; 43(2): 195-201. doi: 10.30476/ijms.2018.40528

Amelioration of Pentylenetetrazole-Induced Seizures by Modulators of Sigma, N-Methyl-D-Aspartate, and Ryanodine Receptors in Mice

Iranian Journal of Medical Sciences
مقاله 9، دوره 43، شماره 2، خرداد 2018، صفحه 195-201    اصل مقاله (224.12 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2018.40528
نویسندگان
Mojtaba Keshavarz* 1؛ Behdad Yekzaman2
1Department of Pharmacology, Bushehr University of Medical Sciences, Bushehr, Iran; and Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;
2School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
چکیده
Background: Sigma receptors, N-methyl-D-aspartate (NMDA) antagonist, and modulators of intracellular calcium may be useful for seizure control. Therefore, we aimed to evaluate the antiepileptic effects of opipramol, a sigma receptor agonist, against pentylenetetrazole (PTZ)-induced seizures in mice and assess ketamine and caffeine interaction with the antiepileptic effects of opipramol.Methods: PTZ (100 mg/kg) was used for the induction of seizure in 72 male albino Swiss strain of mice (n=8). Opipramole (10, 20, and 50 mg/kg), ketamine (50 mg/kg), caffeine (200 mg/kg), opipramole (20 mg/kg) plus ketamine (50 mg/kg), opipramole (20 mg/kg) plus caffeine (200 mg/kg), diazepam (5 mg/kg as a positive control), and the vehicle were administered interaperitoneally 30 minutes before the injection of PTZ. The latency was recorded for the clonic, tonic-clonic seizures, and death of animals after the injection of PTZ. Kruskal-Wallis test followed by Dunn’s test was used for the analysis of data. Statistical analysis was performed with the SPSS software version 23.0 and P
کلیدواژه‌ها
Opipramol؛ Sigma؛ Pentylenetetrazole؛ Ketamine؛ Caffeine
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