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The Preventive Role of Pioglitazone in Glycerol-Induced Acute Kidney Injury in Rats during Two Different Treatment Periods | ||
| Iranian Journal of Medical Sciences | ||
| مقاله 8، دوره 43، شماره 2، خرداد 2018، صفحه 184-194 اصل مقاله (2.35 M) | ||
| نوع مقاله: Original Article(s) | ||
| شناسه دیجیتال (DOI): 10.30476/ijms.2018.40527 | ||
| نویسندگان | ||
| Rama Mousleh1؛ Shaza Al Laham* 1؛ Ahmad Al-Manadili2 | ||
| 1Departmentof Pharmacology and Toxicology, Faculty of Pharmacy, Damascus University, Damascus, Syria | ||
| 2Departmentof Oral Histopathology, Faculty of Dentistry, Damascus University, Damascus, Syria | ||
| چکیده | ||
| Background: Acute kidney injury is the most life-threatening complication of rhabdomyolysis. Glycerol is commonly used to induce this injury. The aim was to investigate the renoprotective effects of pioglitazone and the possible advantage of administering the drug for a longer period.Methods: Twenty-four male Albino Wistar rats were randomly divided into 4 groups (n=6/group): (A) control, (B) glycerol (50%, 10 mL/kg intramuscularly), (C) glycerol+pioglitazone (10 mg/kg orally for 3 days), and (D) glycerol+pioglitazone (for 6 days). Serum urea and creatinine levels were measured to assess the renal function. Reduced glutathione (GSH) levels and histological alterations were also measured. Statistical analysis was performed using Prism (version 6). The numerical data were evaluated by ANOVA, followed by the Tukey tests. The categorical data were evaluated by the Mann–Whitney test and the Fisher exact tests. P | ||
| کلیدواژه‌ها | ||
| Kidney؛ Glycerol؛ Rhabdomyolysis؛ Acute kidney injury؛ Pioglitazone؛ Reduced glutathione | ||
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