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Gohari, Ali, Noorafshan, Ali, Akmali, Masoumeh, Zamani-Garmsiri, Fahimeh, Seghatoleslam, Atefeh. (1396). Urtica Dioica Distillate Regenerates Pancreatic Beta Cells in Streptozotocin-Induced Diabetic Rats. سامانه مدیریت نشریات علمی, 43(2), 174-183. doi: 10.30476/ijms.2018.40526
Ali Gohari; Ali Noorafshan; Masoumeh Akmali; Fahimeh Zamani-Garmsiri; Atefeh Seghatoleslam. "Urtica Dioica Distillate Regenerates Pancreatic Beta Cells in Streptozotocin-Induced Diabetic Rats". سامانه مدیریت نشریات علمی, 43, 2, 1396, 174-183. doi: 10.30476/ijms.2018.40526
Gohari, Ali, Noorafshan, Ali, Akmali, Masoumeh, Zamani-Garmsiri, Fahimeh, Seghatoleslam, Atefeh. (1396). 'Urtica Dioica Distillate Regenerates Pancreatic Beta Cells in Streptozotocin-Induced Diabetic Rats', سامانه مدیریت نشریات علمی, 43(2), pp. 174-183. doi: 10.30476/ijms.2018.40526
Gohari, Ali, Noorafshan, Ali, Akmali, Masoumeh, Zamani-Garmsiri, Fahimeh, Seghatoleslam, Atefeh. Urtica Dioica Distillate Regenerates Pancreatic Beta Cells in Streptozotocin-Induced Diabetic Rats. سامانه مدیریت نشریات علمی, 1396; 43(2): 174-183. doi: 10.30476/ijms.2018.40526

Urtica Dioica Distillate Regenerates Pancreatic Beta Cells in Streptozotocin-Induced Diabetic Rats

Iranian Journal of Medical Sciences
مقاله 7، دوره 43، شماره 2، خرداد 2018، صفحه 174-183    اصل مقاله (1.23 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2018.40526
نویسندگان
Ali Gohari1؛ Ali Noorafshan2؛ Masoumeh Akmali1؛ Fahimeh Zamani-Garmsiri1؛ Atefeh Seghatoleslam* 3
1Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Urtica dioica is known as an anti-hyperglycemic plant. Urtica dioica distillate (UD) is a traditional Iranian drink, locally known as “aragh gazaneh”. In spite of its widespread consumption in Iran, according to traditional Iranian medicine, there is no scientific report on the usefulness of UD for diabetic patients. This survey was designed to evaluate its protective effects for the recovery from diabetes by determining the serum insulin, blood glucose, volume of pancreatic islets, and the number and volume of β-cells in diabetic rats.Methods: A total of 48 Sprague-Dawley male rats (200-250 g) were randomly distributed into 6 groups (n=8), including non-diabetic plus distilled water (DW), non-diabetic plus UD, diabetic plus DW, diabetic plus UD, diabetic plus insulin, and diabetic plus glibenclamide. DW, UD, and glibenclamide were administered via intragastric gavage and insulin was injected subcutaneously. After four weeks of experiments, blood samples were collected for serum insulin and blood glucose assay. Pancreas was also evaluated using stereological method. The SPSS software was used for statistical analysis. Kruskal-Wallis, repeated measurements, and Mann-Whitney U test were applied for comparisons between the groups.Results: The treatment of diabetic rats with UD reduced the blood glucose dramatically (P<0.001) and increased serum insulin levels significantly (P=0.03) in comparison to the diabetic plus DW rats. Treatment with UD did not affect the mean β-cell volumes in the diabetic rats when compared to the diabetic plus DW rats, but the islet volumes and β-cell numbers were significantly recovered.Conclusion: UD treatment in diabetic rats improves hyperglycemia by partially restoring plasma insulin levels. The data suggest that UD prevents islet atrophy and/or regenerate pancreatic β-cells.
کلیدواژه‌ها
diabetes mellitus؛ Pancreatic beta cell؛ Urtica dioica distillate؛ Rats؛ Streptozotocin
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