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Setyaningsih, Wiwit, Arfian, Nur, Suryadi, Efrayim, Romi, Muhammad, Tranggono, Untung, Sari, Dwi. (1396). Hyperuricemia Induces Wnt5a/Ror2 Gene Expression, Epithelial–Mesenchymal Transition, and Kidney Tubular Injury in Mice. سامانه مدیریت نشریات علمی, 43(2), 164-173. doi: 10.30476/ijms.2018.40525
Wiwit Ananda Wahyu Setyaningsih; Nur Arfian; Efrayim Suryadi; Muhammad Mansyur Romi; Untung Tranggono; Dwi Cahyani Ratna Sari. "Hyperuricemia Induces Wnt5a/Ror2 Gene Expression, Epithelial–Mesenchymal Transition, and Kidney Tubular Injury in Mice". سامانه مدیریت نشریات علمی, 43, 2, 1396, 164-173. doi: 10.30476/ijms.2018.40525
Setyaningsih, Wiwit, Arfian, Nur, Suryadi, Efrayim, Romi, Muhammad, Tranggono, Untung, Sari, Dwi. (1396). 'Hyperuricemia Induces Wnt5a/Ror2 Gene Expression, Epithelial–Mesenchymal Transition, and Kidney Tubular Injury in Mice', سامانه مدیریت نشریات علمی, 43(2), pp. 164-173. doi: 10.30476/ijms.2018.40525
Setyaningsih, Wiwit, Arfian, Nur, Suryadi, Efrayim, Romi, Muhammad, Tranggono, Untung, Sari, Dwi. Hyperuricemia Induces Wnt5a/Ror2 Gene Expression, Epithelial–Mesenchymal Transition, and Kidney Tubular Injury in Mice. سامانه مدیریت نشریات علمی, 1396; 43(2): 164-173. doi: 10.30476/ijms.2018.40525

Hyperuricemia Induces Wnt5a/Ror2 Gene Expression, Epithelial–Mesenchymal Transition, and Kidney Tubular Injury in Mice

Iranian Journal of Medical Sciences
مقاله 6، دوره 43، شماره 2، خرداد 2018، صفحه 164-173    اصل مقاله (1.39 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2018.40525
نویسندگان
Wiwit Ananda Wahyu Setyaningsih1؛ Nur Arfian* 2؛ Efrayim Suryadi؛ Muhammad Mansyur Romi؛ Untung Tranggono؛ Dwi Cahyani Ratna Sari
1Department of Anatomy Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia
2Department of Anatomy Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Pharmaco Street, North Sekip, Yogyakarta 55281, Indonesia
چکیده
Background: Hyperuricemia contributes to kidney injury, characterized by tubular injury with epithelial–mesenchymal transition (EMT). Wnt5a/Ror2 signaling drives EMT in many kidney pathologies. This study sought to evaluate the involvement of Wnt5a/Ror2 in hyperuricemia-induced EMT in kidney tubular injury.Methods: A hyperuricemia model was performed in male Swiss background mice (3 months old, 30–40 g) with daily intraperitoneal injections of 125 mg/kg body weight (BW) of uric acid. The mice were terminated on day 7 (UA7, n=5) and on day 14 (UA14, n=5). Allopurinol groups (UAl7 and UAl14, each n=5) were added with oral 50 mg/kg BW of allopurinol treatment. The serum uric acid level was quantified, and tubular injury was assessed based on PAS staining. Reverse transcriptase-PCR was done to quantify Wnt5a, Ror2, E-cadherin, and vimentin expressions. IHC staining was done for E-cadherin and collagen I. We used the Shapiro–Wilk for normality testing and one-way ANOVA for variance analysis with a P
کلیدواژه‌ها
Hyperuricemia؛ Tubular injury؛ E-cadherin gene expression؛ Vimentin؛ Gene expression؛ Wnt5a/Ror2
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