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First Report on the Percentiles of the Glomerular Filtration Rate in Iranian Children Using the 2009 Schwartz Equations | ||
| Iranian Journal of Medical Sciences | ||
| مقاله 10، دوره 43، شماره 2، خرداد 2018، صفحه 202-207 اصل مقاله (814.94 K) | ||
| نوع مقاله: Brief Report(s) | ||
| شناسه دیجیتال (DOI): 10.30476/ijms.2018.40515 | ||
| نویسندگان | ||
| Peyman Roomizadeh1؛ Alaleh Gheissari2؛ Roya Kelishadi3؛ Farhad Mahmoudi4؛ Amin Abedini* 5 | ||
| 1School of Medicine, Iran University of Medical Sciences, Tehran, Iran | ||
| 2Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; and Department of Pediatric Nephrology, Isfahan University of Medical Sciences, Isfahan, Iran | ||
| 3Child Growth and Development Research Center, Department of Pediatrics, Isfahan University of Medical Sciences, Isfahan, Iran; | ||
| 4Medical Students’ Research Center, Isfahan University of Medical sciences, Isfahan, Iran | ||
| 5Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran | ||
| چکیده | ||
| The glomerular filtration rate (GFR) is widely considered the best overall index of renal function. The Schwartz equations are designed for measuring the GFR in children between 1 and 16 years of age. In the present study, we investigated the percentiles of the GFR in a general population of Iranian children with no known renal disease via the 2009 Schwartz equations (updated and combined equations). Between 2010 and 2011, we selected 687 children aged 7–16 years from the Iranian province of Isfahan. Blood samples were analyzed for blood urea nitrogen, creatinine, and cystatin C. For each child, we calculated the GFR using 2 Schwartz equations. The Wilcoxon test was applied to examine the differences in the estimated GFRs between the equations. To determine the correlation between the GFRs obtained via the updated and combined Schwartz equations in the boys and the girls and also for the correlation between age and the GFR, we performed the Pearson or Spearman correlation coefficients. The statistical analyses were conducted using MedCalc, version 12.1.4.0 (MedCalc Software, Mariakerke, Belgium). The mean GFR was 100.06±19.80 mL/min/1.73 m2 based on the updated equation and 96.10±18.44 mL/min/1.73 m2 according to the combined equation. No significant differences were observed between these equations in estimating the GFRs. The correlation analysis for determining the association between age and the GFR estimated by the updated (r=0.05, P=0.1) and combined (r=0.06, P=0.09) Schwartz equations was not statistically significant. In conclusion, in the current study we showed that the updated and combined Schwartz equations exhibited high concordance in estimating GFR values in this age group. | ||
| کلیدواژه‌ها | ||
| Glomerular filtration rate؛ Pediatrics؛ Cystatin C؛ Iran | ||
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