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Vasudeva, Vidya, Tenkanidiyoor, Yogish Somayaji, Peter, Alex John, Shetty, Jayaram, Lakshman, Srikant Patil, Fernandes, Ronald, Patali, Krishna Ananthapura. (1396). Radioprotective Efficacy of Lutein in Ameliorating Electron Beam Radiation-induced Oxidative Injury in Swiss Albino Mice. سامانه مدیریت نشریات علمی, 43(1), 41-51. doi: 10.30476/ijms.2018.40512
Vidya Vasudeva; Yogish Somayaji Tenkanidiyoor; Alex John Peter; Jayaram Shetty; Srikant Patil Lakshman; Ronald Fernandes; Krishna Ananthapura Patali. "Radioprotective Efficacy of Lutein in Ameliorating Electron Beam Radiation-induced Oxidative Injury in Swiss Albino Mice". سامانه مدیریت نشریات علمی, 43, 1, 1396, 41-51. doi: 10.30476/ijms.2018.40512
Vasudeva, Vidya, Tenkanidiyoor, Yogish Somayaji, Peter, Alex John, Shetty, Jayaram, Lakshman, Srikant Patil, Fernandes, Ronald, Patali, Krishna Ananthapura. (1396). 'Radioprotective Efficacy of Lutein in Ameliorating Electron Beam Radiation-induced Oxidative Injury in Swiss Albino Mice', سامانه مدیریت نشریات علمی, 43(1), pp. 41-51. doi: 10.30476/ijms.2018.40512
Vasudeva, Vidya, Tenkanidiyoor, Yogish Somayaji, Peter, Alex John, Shetty, Jayaram, Lakshman, Srikant Patil, Fernandes, Ronald, Patali, Krishna Ananthapura. Radioprotective Efficacy of Lutein in Ameliorating Electron Beam Radiation-induced Oxidative Injury in Swiss Albino Mice. سامانه مدیریت نشریات علمی, 1396; 43(1): 41-51. doi: 10.30476/ijms.2018.40512

Radioprotective Efficacy of Lutein in Ameliorating Electron Beam Radiation-induced Oxidative Injury in Swiss Albino Mice

Iranian Journal of Medical Sciences
مقاله 6، دوره 43، شماره 1، فروردین 2018، صفحه 41-51    اصل مقاله (862.88 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2018.40512
نویسندگان
Vidya Vasudeva1؛ Yogish Somayaji Tenkanidiyoor1؛ Alex John Peter2؛ Jayaram Shetty2؛ Srikant Patil Lakshman3؛ Ronald Fernandes4؛ Krishna Ananthapura Patali* 3
1Central Research Laboratory(CRL), K S Hegde Medical Academy, Nitte University, Mangalore, Karnataka
2Department of Oncology, Nitte Leela Narayana Shetty Memorial Cancer Institute, Mangalore, Karnataka
3Department of Physiology, K S Hegde Medical Academy, Nitte University, Mangalore, Karnataka
4Department of Biochemistry, Nitte Gulabi Shetty Memorial Institute of Pharmaceutical Sciences, Nitte University, Mangalore, Karnataka
چکیده
Background: Lutein, a carotenoid compound, has previously been studied for its antioxidant and medicinal properties as well as the moderate protection it confers against gamma radiation. This study aimed at evaluating the effects of lutein against radiation-induced hematological and biochemical changes in mice.Methods: The optimized dose of the compound was orally administered for 15 days, and the mice were irradiated (6 Gy) on day 15 after the administration of the compound. The groups were divided (6 mice in each group) into normal control, radiation control, gallic acid control, 10% DMSO control, lutein control, and irradiated groups pretreated with gallic acid, 10% DMSO, and lutein. Gallic acid was used to maintain a standard since it is a proven radioprotector. Within 24 hours post irradiation, the animals were anesthetized and sacrificed. The hematological, biochemical, and antioxidant changes were determined using suitable methods. Data were analyzed by the Kaplan–Meier curve (log-rank test) and ANOVA (the Tukey test). The independent t test was used to compare the independent groups. SPSS (ver. 16) was employed. Results: Maximum survival was observed with a dose of 250 mg/kg b.wt lutein. The total leukocyte count and the percentage lymphocyte count exhibited a significant decline in the irradiated groups pretreated with gallic acid and lutein in comparison to their controls, whereas the percentage granulocyte count showed a significant rise. Antioxidant activity had markedly declined in the irradiated groups, indicating oxidative stress. Lutein pretreatment reduced the damage and maintained the antioxidant system.Conclusion: The present study suggests a protective role for lutein in palliating radiation-induced oxidative changes and maintaining the antioxidant system in vivo.
کلیدواژه‌ها
Antioxidants؛ Carotenoids؛ Lutein؛ Oxidative stress
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