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Shidfar, Farzad, Faghihi, Amirhosein, Lorvand Amiri, Hamid, Mousavi, Seyedeh Neda. (1396). Regression of Nonalcoholic Fatty Liver Disease with Zinc and Selenium Co-supplementation after Disease Progression in Rats. سامانه مدیریت نشریات علمی, 43(1), 26-31. doi: 10.30476/ijms.2018.40508
Farzad Shidfar; Amirhosein Faghihi; Hamid Lorvand Amiri; Seyedeh Neda Mousavi. "Regression of Nonalcoholic Fatty Liver Disease with Zinc and Selenium Co-supplementation after Disease Progression in Rats". سامانه مدیریت نشریات علمی, 43, 1, 1396, 26-31. doi: 10.30476/ijms.2018.40508
Shidfar, Farzad, Faghihi, Amirhosein, Lorvand Amiri, Hamid, Mousavi, Seyedeh Neda. (1396). 'Regression of Nonalcoholic Fatty Liver Disease with Zinc and Selenium Co-supplementation after Disease Progression in Rats', سامانه مدیریت نشریات علمی, 43(1), pp. 26-31. doi: 10.30476/ijms.2018.40508
Shidfar, Farzad, Faghihi, Amirhosein, Lorvand Amiri, Hamid, Mousavi, Seyedeh Neda. Regression of Nonalcoholic Fatty Liver Disease with Zinc and Selenium Co-supplementation after Disease Progression in Rats. سامانه مدیریت نشریات علمی, 1396; 43(1): 26-31. doi: 10.30476/ijms.2018.40508

Regression of Nonalcoholic Fatty Liver Disease with Zinc and Selenium Co-supplementation after Disease Progression in Rats

Iranian Journal of Medical Sciences
مقاله 4، دوره 43، شماره 1، فروردین 2018، صفحه 26-31    اصل مقاله (655.48 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2018.40508
نویسندگان
Farzad Shidfar1؛ Amirhosein Faghihi2؛ Hamid Lorvand Amiri3؛ Seyedeh Neda Mousavi* 4
1Iran National Science Foundation, Tehran, Iran; Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran; and Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran
2Iran National Science Foundation, Tehran, Iran; and Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran
3Iran National Science Foundation, Tehran, Iran; and Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
4Iran National Science Foundation, Tehran, Iran; and Department of Biochemistry and Nutrition, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
چکیده
Background: Studies have shown that zinc and selenium deficiency is common in nonalcoholic fatty liver disease (NAFLD). However, the effects of zinc and selenium co-supplementation before and/or after disease progression on NAFLD are not clear enough. The aim of this study was to compare the effects of zinc and selenium co-supplementation before and/or after disease progression on NAFLD prognosis.Methods: Forty male Sprague–Dawley rats (197±4 g) were randomly assigned to 4 dietary groups: normal-fat diet (NFD; receiving 9% of calories as fat), high-fat diet (HFD; receiving 82% of calories as fat), supplementation before disease progression (S+HFD), and supplementation after disease progression (HFD+S). The diets were implemented over a 20-week period in all the groups. Biochemical and histologic parameters were compared between the 4 groups, and between-group comparisons were also carried out.Results: There were significant differences in the average food dietary intake (P
کلیدواژه‌ها
Fatty liver؛ Trigelycerids؛ Lipid profile؛ Selenium؛ Zink؛ Cholestrol
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