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Effects of Subacute Administration of Co-Trimoxazole and Folic Acid on Ovarian Tissue in Adult Female Rats | ||
| Iranian Journal of Medical Sciences | ||
| مقاله 6، دوره 42، شماره 6، بهمن 2017، صفحه 561-568 اصل مقاله (1.14 M) | ||
| نوع مقاله: Original Article(s) | ||
| نویسندگان | ||
| Arezoo Saberi1؛ Ehsan Salarkia1؛ Zohreh Safi2؛ Gholamreza Sepehri* 3 | ||
| 1Kerman Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran | ||
| 2Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran | ||
| 3Kerman Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran | ||
| چکیده | ||
| Background: Previous studies have reported the antifertility activities of sulfonamides. This study was designed to evaluate the effects of co-trimoxazole and its co-administration with folic acid on ovarian tissue in female rats.Methods: A total of 54 rats were randomly divided into 9 groups (n=6). Group I served as the control and group II (vehicle) received saline. Other groups, III to IX, received co-trimoxazole (30, 60, and 120 mg/kg; i.p.), folic acid (1 mg/kg; i.p.) or their combination for 14 days, respectively. The oocytes were obtained from each group at the end of the 14th days and scored for maturational status as germinal vesicle (GV), metaphase I (MI), or metaphase II (MII). The number of primordial follicle (PrF), primary follicle (PF), and secondary follicle in formalin-fixed ovaries were counted under light microscopy. The data were analyzed by one-way ANOVA followed by post-hoc Dunnet test using SPSS statistical software (version 17.0). Results were considered statistically significant at P<0.05.Results: Co-trimoxazole (60 and 120 mg/kg) treatment for 14 days caused a significant decrease in the number of GV (P=0.02, P<0.001), MI and MII (P=0.03, P<0.001), a significant increase in structural abnormalities, including PrF, PF and secondary follicle (P<0.001) as well as congestion, inflammation and necrosis of ovarian tissue compared to the vehicle group. Folic acid co-administration with co-trimoxazole reversed partially all these parameters compared to the co-trimoxazole group (P<0.001).Conclusion: The data showed the adverse effects of co-trimoxazole on the ovarian maturational status and tissue structure which was reversed partially by folic acid co-administration in rats. | ||
| کلیدواژهها | ||
| Cotrimoxazole؛ Folic acid؛ Ovarian maturation status؛ Ovarian histopathology؛ Rats | ||
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