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Hatanaka, Yoshihiro, Inoue, Satoru, Goto, Koji, Yasuda, Norihisa, Hidaka, Seigo, Kitano, Takaaki. (1396). Vitamin E-Coated Polysulfone Membrane-Based Hemodiafiltration Attenuates Inflammation in a Rat Model of Lipopolysaccharide-Induced Systemic Inflammation. سامانه مدیریت نشریات علمی, 42(5), 465-472.
Yoshihiro Hatanaka; Satoru Inoue; Koji Goto; Norihisa Yasuda; Seigo Hidaka; Takaaki Kitano. "Vitamin E-Coated Polysulfone Membrane-Based Hemodiafiltration Attenuates Inflammation in a Rat Model of Lipopolysaccharide-Induced Systemic Inflammation". سامانه مدیریت نشریات علمی, 42, 5, 1396, 465-472.
Hatanaka, Yoshihiro, Inoue, Satoru, Goto, Koji, Yasuda, Norihisa, Hidaka, Seigo, Kitano, Takaaki. (1396). 'Vitamin E-Coated Polysulfone Membrane-Based Hemodiafiltration Attenuates Inflammation in a Rat Model of Lipopolysaccharide-Induced Systemic Inflammation', سامانه مدیریت نشریات علمی, 42(5), pp. 465-472.
Hatanaka, Yoshihiro, Inoue, Satoru, Goto, Koji, Yasuda, Norihisa, Hidaka, Seigo, Kitano, Takaaki. Vitamin E-Coated Polysulfone Membrane-Based Hemodiafiltration Attenuates Inflammation in a Rat Model of Lipopolysaccharide-Induced Systemic Inflammation. سامانه مدیریت نشریات علمی, 1396; 42(5): 465-472.

Vitamin E-Coated Polysulfone Membrane-Based Hemodiafiltration Attenuates Inflammation in a Rat Model of Lipopolysaccharide-Induced Systemic Inflammation

Iranian Journal of Medical Sciences
مقاله 6، دوره 42، شماره 5، آذر 2017، صفحه 465-472    اصل مقاله (1.11 M)
نوع مقاله: Original Article(s)
نویسندگان
Yoshihiro Hatanaka* 1؛ Satoru Inoue1؛ Koji Goto2؛ Norihisa Yasuda2؛ Seigo Hidaka2؛ Takaaki Kitano2
1Medical Material Laboratory, Asahi Kasei Medical Company, Oaza-Sato, Oita, Japan
2Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine, Oita University, Idaigaoka-Hasamamachi, Yufu City, Oita, Japan
چکیده
Background: Acute blood purification (ABP) therapy is used regularly in the clinical setting and reportedly alleviates organ failure associated with severe systemic inflammatory responses, leading to reduced mortality. The present study aimed to determine whether there is a difference in efficacy between polysulfone (PS) membranes, which are currently used regularly in the clinical setting, and vitamin E-coated polysulfone (VEPS) membranes, which are anticipated to exhibit the antioxidant and anti-inflammatory properties of vitamin E.Methods: Male Wistar rats (n=15/group) were intravenously administered 10 mg/kg of lipopolysaccharide (LPS) to establish a systemic inflammatory response model. Six hours after LPS administration, hemodiafiltration (HDF) was performed for 30 minutes using a PS or VEPS membrane under general anesthesia. Blood was collected at various time points, lung tissue was evaluated histologically, and 24-hour survival was assessed.Results: The rats in the VEPS group tended to have a higher survival rate than those in the PS group when undergoing HDF, although the difference was not significant. With respect to lung tissue, the inflammatory response was suppressed to a greater extent in the VEPS group than the PS group. Serum interleukin (IL)-6 levels were reduced at an early stage, plasma antioxidant activity was increased, and oxidative stress was reduced in the VEPS group compared to the PS group.Conclusion: Relative to PS membrane-based HDF, the survival rate tended to improve and inflammation was subdued earlier due to the antioxidant activity and early attenuation of inflammation associated with VEPS membrane-based HDF.
کلیدواژه‌ها
Vitamin E؛ Inflammatory response؛ Polysulfone؛ Hemodiafiltration؛ Rats
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