پیوندهای مفید
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| تعداد مشاهده مقاله | 27,595,964 |
| تعداد دریافت فایل اصل مقاله | 7,648,490 |
High-Grade Urothelial Carcinoma of Bladder Transforming to Micropapillary Variant on Follow-Up | ||
| Iranian Journal of Medical Sciences | ||
| مقاله 14، دوره 42، شماره 3، مرداد 2017، صفحه 318-321 اصل مقاله (1.11 M) | ||
| نوع مقاله: Case Report(s) | ||
| نویسندگان | ||
| Nitu Kumari1؛ Anupama Jha1؛ Pawan Vasudeva2؛ Usha Agrawal* 1 | ||
| 1National Institute of Pathology, Indian Council of Medical Research, New Delhi, India | ||
| 2Deptt of Urology, VMMC and Safdarjung Hospital, New Delhi, India | ||
| چکیده | ||
| Micropapillary variant of urothelial carcinoma (UC) of the bladder is an aggressive tumour, comprising 0.6-6% of all UC. It generally presents with high-grade and stage, and has been reported as having a worse prognosis when compared to traditional UC. We report the case of a 58-year-old man who presented with macroscopic haematuria. The patient was diagnosed with high-grade urothelial carcinoma and returned with recurrence after 16 months. Histopathology after transurethral biopsy revealed a non-muscle invasive high-grade bladder tumour at first presentation, whereas tumour recurrence was reported after 1.5years. The histopathology at recurrence revealed a high-grade, muscle invasive, micropapillary variant of urothelial carcinoma with focal adenomatous morphology. Immunohistochemical expression of CK7+/CK20+ in tumour cells and negativity for PSA, AMACR, and CDX2 in paraffin section helped in identifying the tumour as primary in the urinary bladder. Radical cystectomy was performed and the patient has no distant metastases on follow-up. The specific morphology even within the high-grade urothelial cancer cases is important to discern for proper treatment. | ||
| کلیدواژهها | ||
| Transitional cell carcinoma؛ Micropapillary variant؛ Bladder | ||
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آمار تعداد مشاهده مقاله: 1,609 تعداد دریافت فایل اصل مقاله: 760 |
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