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Effects of Maternal Isocaloric Diet Containing Different Amounts of Soy Oil and Extra Virgin Olive Oil on Weight, Serum Glucose, and Lipid Profile of Female Mice Offspring | ||
| Iranian Journal of Medical Sciences | ||
| مقاله 6، دوره 42، شماره 2، خرداد 2017، صفحه 161-169 اصل مقاله (788.87 K) | ||
| نوع مقاله: Original Article(s) | ||
| نویسندگان | ||
| Seyedeh Neda Mousavi* 1؛ Fariba Koohdani1؛ Farzad Shidfar2؛ Mohamadreza Baghban Eslaminejad3؛ Pantea Izadi4؛ Mohamadreza Eshraghian5؛ Leila Shafieineek6؛ Hamidreza Tohidinik7 | ||
| 1Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran | ||
| 2Department of Nutrition, School of Public Health, Colorectal Research Center, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran | ||
| 3Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran | ||
| 4Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran | ||
| 5Department of Statistics, School of Health, Tehran University of Medical Sciences, Tehran, Iran | ||
| 6Department of Sport Physiology, School of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran | ||
| 7School of Public Health, Gonabad University of Medical Sciences, Gonabad, Iran | ||
| چکیده | ||
| Background: Health status of offspring is programmed by maternal diet throughout gestation and lactation. The present study investigates the lasting effects of maternal supplementation with different amounts of soy oil or extra virgin olive oil (EVOO) on weight and biochemical parameters during gestation and lactation of female mice offspring.Methods: Eight weeks old female C57BL/6 mice (n=40) were assigned through simple randomization into four isocaloric dietary groups (16% of calories as soy oil (LSO) or EVOO (LOO) and 45% of calories as soy oil (HSO) or EVOO (HOO)) during three weeks of gestation and lactation. After weaning (at 3 weeks), all offspring received a diet containing 16% of calories as soy oil and were sacrificed at 6 weeks. Two-way ANOVA was used to adjust for confounding variables and repeated measures test for weight gain trend. Statistical analyses were performed with the IBM SPSS package.Results: At birth and adolescence, the weight of offspring was significantly higher in the soy oil than the olive oil groups (P<0.001 and P<0.001, respectively). Adolescence weight was significantly higher in the offspring born to mothers fed with 16% oil than those with 45% oil (P=0.001). Serum glucose, triglyceride and total cholesterol were significantly higher in the LSO than LOO (P<0.001, P<0.001 and P<0.001), LSO than HSO (P<0.001, P=0.03 and P<0.001), and LOO than HOO (P<0.001, P<0.001 and P<0.001) dietary groups, respectively. Serum triglyceride and total cholesterol were significantly higher in the offspring of HSO than HOO fed mothers (P<0.001 and P<0.001, respectively).Conclusion: A maternal diet containing EVOO has better effects on birth weight, as well as weight and serum biochemical parameters in offspring at adolescence. | ||
| کلیدواژهها | ||
| Diet؛ Body weight؛ Lipid profile؛ Glucose؛ Multiple birth offspring | ||
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