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Haidari, Fatemeh, Zakerkish, Mehrnoosh, Karandish, Majid, Saki, Azadeh, Pooraziz, Sakineh. (1395). Association between Serum Vitamin D Level and Glycemic and Inflammatory Markers in Non-obese Patients with Type 2 Diabetes. سامانه مدیریت نشریات علمی, 41(5), 367-373.
Fatemeh Haidari; Mehrnoosh Zakerkish; Majid Karandish; Azadeh Saki; Sakineh Pooraziz. "Association between Serum Vitamin D Level and Glycemic and Inflammatory Markers in Non-obese Patients with Type 2 Diabetes". سامانه مدیریت نشریات علمی, 41, 5, 1395, 367-373.
Haidari, Fatemeh, Zakerkish, Mehrnoosh, Karandish, Majid, Saki, Azadeh, Pooraziz, Sakineh. (1395). 'Association between Serum Vitamin D Level and Glycemic and Inflammatory Markers in Non-obese Patients with Type 2 Diabetes', سامانه مدیریت نشریات علمی, 41(5), pp. 367-373.
Haidari, Fatemeh, Zakerkish, Mehrnoosh, Karandish, Majid, Saki, Azadeh, Pooraziz, Sakineh. Association between Serum Vitamin D Level and Glycemic and Inflammatory Markers in Non-obese Patients with Type 2 Diabetes. سامانه مدیریت نشریات علمی, 1395; 41(5): 367-373.

Association between Serum Vitamin D Level and Glycemic and Inflammatory Markers in Non-obese Patients with Type 2 Diabetes

Iranian Journal of Medical Sciences
مقاله 1، دوره 41، شماره 5، آذر 2016، صفحه 367-373    اصل مقاله (446.06 K)
نوع مقاله: Original Article(s)
نویسندگان
Fatemeh Haidari1؛ Mehrnoosh Zakerkish2؛ Majid Karandish1؛ Azadeh Saki3؛ Sakineh Pooraziz* 1
1Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2Health Research Institute, Diabetes Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3Department of Biostatistics, Faculty of Medical Science, Ahvaz Jundishapur University of Medical sciences, Ahvaz, Iran
چکیده
Background: Low serum 25-hydroxy vitamin D (25(OH)D) has been shown to correlate with an increased risk of type 2 diabetes mellitus (T2DM). The objective of this study was to investigate the association between serum 25(OH)D and glycemic and inflammatory markers in non-obese patients with T2DM. Methods: Eighty-four non-obese patients with T2DM were recruited in this cross-sectional study. Demographic, anthropometric, and dietary information was obtained from all the participants. The serum concentrations of glucose, HbA1C, insulin, 25(OH)D, and inflammatory markers including tumor necrosis factor-alpha (TNF-α) and high sensitive C-reactive protein (hs-CRP) were measured. A homeostatic model of insulin resistance (HOMA-IR) was also evaluated.Results: The mean serum concentration of 25(OH)D was 11.01±5.55 ng/mL. Severe deficiency, deficiency, and insufficiency of vitamin D were detected in 60.71%, 35.72%, and 3.57% of the participants, respectively. The results showed that those in the lowest group of serum 25(OH)D had significantly higher TNF-α than did those in the highest group (P=0.026). Although the association between serum 25(OH)D and fasting blood sugar and TNF-α was statistically significant (P=0.049 and P=0.044, respectively), the other glycemic markers and hs-CRP did not have any significant relationships with 25(OH)D. Conclusion: According to the high prevalence of vitamin D deficiency in the diabetic patients and the inverse relationship between serum 25(OH)D and fasting blood sugar and TNF-α in this study, vitamin D status may be a determining factor of systemic inflammation in patients with T2DM. Further studies with larger sample sizes are suggested in this regard.
کلیدواژه‌ها
diabetes mellitus؛ Type 2؛ Inflammatory factors؛ Obesity؛ Vitamin D
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