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Khorsand, Marjan, Akmali, Masoumeh, Sharzad, Sahab, Beheshtitabar, Mojtaba. (1395). Melatonin Reduces Cataract Formation and Aldose Reductase Activity in Lenses of Streptozotocin-induced Diabetic Rat. سامانه مدیریت نشریات علمی, 41(4), 305-313.
Marjan Khorsand; Masoumeh Akmali; Sahab Sharzad; Mojtaba Beheshtitabar. "Melatonin Reduces Cataract Formation and Aldose Reductase Activity in Lenses of Streptozotocin-induced Diabetic Rat". سامانه مدیریت نشریات علمی, 41, 4, 1395, 305-313.
Khorsand, Marjan, Akmali, Masoumeh, Sharzad, Sahab, Beheshtitabar, Mojtaba. (1395). 'Melatonin Reduces Cataract Formation and Aldose Reductase Activity in Lenses of Streptozotocin-induced Diabetic Rat', سامانه مدیریت نشریات علمی, 41(4), pp. 305-313.
Khorsand, Marjan, Akmali, Masoumeh, Sharzad, Sahab, Beheshtitabar, Mojtaba. Melatonin Reduces Cataract Formation and Aldose Reductase Activity in Lenses of Streptozotocin-induced Diabetic Rat. سامانه مدیریت نشریات علمی, 1395; 41(4): 305-313.

Melatonin Reduces Cataract Formation and Aldose Reductase Activity in Lenses of Streptozotocin-induced Diabetic Rat

Iranian Journal of Medical Sciences
مقاله 7، دوره 41، شماره 4، مهر 2016، صفحه 305-313    اصل مقاله (511.1 K)
نوع مقاله: Original Article(s)
نویسندگان
Marjan Khorsand1؛ Masoumeh Akmali* 2؛ Sahab Sharzad3؛ Mojtaba Beheshtitabar1
1Department of Biochemistry and Molecular Biology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2Department of Biochemistry, Shiraz University of Medical Sciences, Shiraz, Iran
3Department of Ophthalmology, Khalili Hospital, Shiraz University of Medical sciences, Shiraz, Iran
چکیده
Background: The relationship between the high activity of aldose reductase (AR) and diabetic cataract formation has been previously investigated. The purpose of the present study was to determine the preventing effect of melatonin on streptozotocin (STZ)-induced diabetic cataract in rats.Methods: 34 adult healthy male Sprague-Dawely rats were divided into four groups. Diabetic control and diabetic+melatonin received a single dose of STZ (50 mg/kg, intraperitoneally), whereas the normal control and normal+melatonin received vehicle. The melatonin groups were gavaged with melatonin (5 mg/kg) daily for a period of 8 weeks, whereas the rats in the normal control and diabetic control groups received only the vehicle. The rats’ eyes were examined every week and cataract formation scores (0-4) were determined by slit-lamp microscope. At the end of the eighth week, the rats were sacrificed and markers of the polyol pathway and antioxidative (Glutathione, GSH) in their lens were determined. The levels of blood glucose, HbA1c and plasma malondialdhyde (MDA), as a marker of lipid peroxidation, were also measured.Results: Melatonin prevented STZ-induced hyperglycemia by decreased blood glucose and HbA1c levels. Slit lamp examination indicated that melatonin delayed cataract progression in diabetic rats. The results revealed that melatonin feeding increased the GSH levels, decreased the activities of AR and sorbitol dehydrogenase (SDH) and sorbitol formation in catractous lenses as well as plasma MDA content. Conclusion: In summary, for the first time we demonstrated that melatonin delayed the formation and progression of cataract in diabetic rat lenses.
کلیدواژه‌ها
Aldose reductase؛ diabetes mellitus؛ Melatonin؛ Cataract؛ Sorbitol dehydrogenase
مراجع
  1. Reiter RJ, Tan DX, Mayo JC, Sainz RM, Leon J, Czarnocki Z. Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans. Acta Biochim Pol. 2003;50:1129-46. doi: 0350041129. PubMed PMID: 14740000.
  2. Dubocovich ML, Markowska M. Functional MT1 and MT2 melatonin receptors in mammals. Endocrine. 2005;27:101-10. doi: 10.1385/ENDO:27:2:101. PubMed PMID: 16217123.
  3. Akmali M, Ahmadi R, Vessal M. Pre- and post-treatment of streptozocin administered rats with melatonin: effects on some hepatic enzymes of carbohydrate metabolism. Arch Iran Med. 2010;13:105-10. PubMed PMID: 20187663.
  4. Galano A, Tan DX, Reiter RJ. Melatonin as a natural ally against oxidative stress: a physicochemical examination. J Pineal Res. 2011;51:1-16. doi: 10.1111/j.1600-079X.2011.00916.x. PubMed PMID: 21752095.
  5. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001;414:813-20. doi: 10.1038/414813a. PubMed PMID: 11742414.
  6. Suryanarayana P, Saraswat M, Petrash JM, Reddy GB. Emblica officinalis and its enriched tannoids delay streptozotocin-induced diabetic cataract in rats. Mol Vis. 2007;13:1291-7. PubMed PMID: 17679931.
  7. Reddy AB, Tammali R, Mishra R, Srivastava S, Srivastava SK, Ramana KV. Aldose reductase deficiency protects sugar-induced lens opacification in rats. Chem Biol Interact. 2011;191:346-50. doi: 10.1016/j.cbi.2011.02.028. PubMed PMID: 21376710; PubMed Central PMCID: PMC3103638.
  8. Thiraphatthanavong P, Wattanathorn J, Muchimapura S, Wipawee TM, Wannanon P, Terdthai TU, et al. Preventive effect of Zea mays L. (purple waxy corn) on experimental diabetic cataract. Biomed Res Int. 2014;2014:507435. doi: 10.1155/2014/507435. PubMed PMID: 24527449; PubMed Central PMCID: PMC3914321.
  9. Hashim Z, Zarina S. Osmotic stress induced oxidative damage: possible mechanism of cataract formation in diabetes. J Diabetes Complications. 2012;26:275-9. doi: 10.1016/j.jdiacomp.2012.04.005. PubMed PMID: 22609218.
  10. Chung YS, Choi YH, Lee SJ, Choi SA, Lee JH, Kim H, et al. Water extract of Aralia elata prevents cataractogenesis in vitro and in vivo. J Ethnopharmacol. 2005;101:49-54. doi: 10.1016/j.jep.2005.03.020. PubMed PMID: 15905053.
  11. Giblin FJ. Glutathione: a vital lens antioxidant. J Ocul Pharmacol Ther. 2000;16:121-35. doi: 10.1089/jop.2000.16.121. PubMed PMID: 10803423.
  12. Zhang S, Chai FY, Yan H, Guo Y, Harding JJ. Effects of N-acetylcysteine and glutathione ethyl ester drops on streptozotocin-induced diabetic cataract in rats. Mol Vis. 2008;14:862-70. PubMed PMID: 18490958; PubMed Central PMCID: PMC2386505.
  13. Kawakubo K, Mori A, Sakamoto K, Nakahara T, Ishii K. GP-1447, an inhibitor of aldose reductase, prevents the progression of diabetic cataract in rats. Biol Pharm Bull. 2012;35:866-72. doi: 10.1248/bpb.35.866. PubMed PMID: 22687477.
  14. Wormstone IM. Posterior capsule opacification: a cell biological perspective. Exp Eye Res. 2002;74:337-47. doi: 10.1006/exer.2001.1153. PubMed PMID: 12014915.
  15. Kocer I, Taysi S, Ertekin MV, Karslioglu I, Gepdiremen A, Sezen O, et al. The effect of L-carnitine in the prevention of ionizing radiation-induced cataracts: a rat model. Graefes Arch Clin Exp Ophthalmol. 2007;245:588-94. doi: 10.1007/s00417-005-0097-1. PubMed PMID: 16915402.
  16. Karslioglu I, Ertekin MV, Taysi S, Kocer I, Sezen O, Gepdiremen A, et al. Radioprotective effects of melatonin on radiation-induced cataract. J Radiat Res. 2005;46:277-82. doi: 10.1269/jrr.46.277. PubMed PMID: 15988147.
  17. Shirazi A, Haddadi GH, Asadi-Amoli F, Sakhaee S, Ghazi-Khansari M, Avand A. Radioprotective effect of melatonin in reducing oxidative stress in rat lenses. Cell J. 2011;13:79-82. PubMed PMID: 23508093; PubMed Central PMCID: PMC3584458.
  18. Preet A, Gupta BL, Yadava PK, Baquer NZ. Efficacy of lower doses of vanadium in restoring altered glucose metabolism and antioxidant status in diabetic rat lenses. J Biosci. 2005;30:221-30. doi: 10.1007/BF02703702. PubMed PMID: 15886458.
  19. Corcoran A, Page IH. A method for the determination of mannitol in plasma and urine. Journal of Biological Chemistry. 1947;170:165-71.
  20. Barros PS, Angelotti AC, Nobre F, Morales A, Fantoni DT, Barros SB. Antioxidant profile of cataractous English Cocker Spaniels. Vet Ophthalmol. 1999;2:83-6. doi: 10.1046/j.1463-5224.1999.00056.x. PubMed PMID: 11397247.
  21. Tietze F. Enzymatic method for quantitative determination of nano gram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem. 1969;27:502S-22S.
  22. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-54. doi: 10.1016/0003-2697(76)90527-3. PubMed PMID: 942051.
  23. Li X, Zhang M, Tang W. Effects of melatonin on streptozotocin-induced retina neuronal apoptosis in high blood glucose rat. Neurochem Res. 2013;38:669-76. doi: 10.1007/s11064-012-0966-z. PubMed PMID: 23299510.
  24. Batcioglu K, Karagozler AA, Genc M, Celik S. Comparison of the chemopreventive potentials of melatonin and vitamin E plus selenium on 7,12-dimethylbenz[a]anthracene-induced inhibition of mouse liver antioxidant enzymes. Eur J Cancer Prev. 2002;11:57-61. PubMed PMID: 11917209.
  25. Aktoz T, Aydogdu N, Alagol B, Yalcin O, Huseyinova G, Atakan IH. The protective effects of melatonin and vitamin E against renal ischemia-reperfusion injury in rats. Ren Fail. 2007;29:535-42. doi: 10.1080/08860220701391738. PubMed PMID: 17654314.
  26. Abdel-Wahab MH, Abd-Allah AR. Possible protective effect of melatonin and/or desferrioxamine against streptozotocin-induced hyperglycaemia in mice. Pharmacol Res. 2000;41:533-7. doi: 10.1006/phrs.1999.0614. PubMed PMID: 10753552.
  27. Anwar MM, Meki AR. Oxidative stress in streptozotocin-induced diabetic rats: effects of garlic oil and melatonin. Comp Biochem Physiol A Mol Integr Physiol. 2003;135:539-47. doi: 10.1016/S1095-6433(03)00114-4. PubMed PMID: 12890544.
  28. Korkmaz A, Ma S, Topal T, Rosales-Corral S, Tan DX, Reiter RJ. Glucose: a vital toxin and potential utility of melatonin in protecting against the diabetic state. Mol Cell Endocrinol. 2012;349:128-37. doi: 10.1016/j.mce.2011.10.013. PubMed PMID: 22079284.
  29. Fabis M, Pruszynska E, Mackowiak P. In vivo and in situ action of melatonin on insulin secretion and some metabolic implications in the rat. Pancreas. 2002;25:166-9. PubMed PMID: 12142740.
  30. Munoz-Casares FC, Padillo FJ, Briceno J, Collado JA, Munoz-Castaneda JR, Ortega R, et al. Melatonin reduces apoptosis and necrosis induced by ischemia/reperfusion injury of the pancreas. J Pineal Res. 2006;40:195-203. doi: 10.1111/j.1600-079X.2005.00291.x. PubMed PMID: 16499554.
  31. Yavuz O, Cam M, Bukan N, Guven A, Silan F. Protective effect of melatonin on beta-cell damage in streptozotocin-induced diabetes in rats. Acta Histochem. 2003;105:261-6. PubMed PMID: 13677620.
  32. Yu JX, Yin XX, Shen JP, Qiu J, Yin HL, Jiang SJ. Protective effects of bendazac lysine on diabetic peripheral neuropathy in streptozotocin-induced diabetic rats. Clin Exp Pharmacol Physiol. 2006;33:1231-8. doi: 10.1111/j.1440-1681.2006.04515.x. PubMed PMID: 17184506.
  33. Klepac N, Rudes Z, Klepac R. Effects of melatonin on plasma oxidative stress in rats with streptozotocin induced diabetes. Biomed Pharmacother. 2006;60:32-5. doi: 10.1016/j.biopha.2005.08.005. PubMed PMID: 16332428.
  34. Suryanarayana P, Saraswat M, Mrudula T, Krishna TP, Krishnaswamy K, Reddy GB. Curcumin and turmeric delay streptozotocin-induced diabetic cataract in rats. Invest Ophthalmol Vis Sci. 2005;46:2092-9. doi: 10.1167/iovs.04-1304. PubMed PMID: 15914628.
  35. Abe M, Reiter RJ, Orhii PB, Hara M, Poeggeler B. Inhibitory effect of melatonin on cataract formation in newborn rats: evidence for an antioxidative role for melatonin. J Pineal Res. 1994;17:94-100. doi: 10.1111/j.1600-079X.1994.tb00119.x. PubMed PMID: 7869232.
  36. Baydas G, Reiter RJ, Yasar A, Tuzcu M, Akdemir I, Nedzvetskii VS. Melatonin reduces glial reactivity in the hippocampus, cortex, and cerebellum of streptozotocin-induced diabetic rats. Free Radic Biol Med. 2003;35:797-804. doi: 10.1016/S0891-5849(03)00408-8. PubMed PMID: 14583344.
  37. Vural H, Sabuncu T, Arslan SO, Aksoy N. Melatonin inhibits lipid peroxidation and stimulates the antioxidant status of diabetic rats. J Pineal Res. 2001;31:193-8. doi: 10.1034/j.1600-079X.2001.310301.x. PubMed PMID: 11589752.
  38. Baydas G, Canatan H, Turkoglu A. Comparative analysis of the protective effects of melatonin and vitamin E on streptozocin-induced diabetes mellitus. J Pineal Res. 2002;32:225-30. doi: 10.1034/j.1600-079X.2002.01856.x. PubMed PMID: 11982791.
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