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Tamaddon, Gholamhossein, Geramizadeh, Bita, Karimi, Mohammad Hossein, Mowla, Seyed Javad, Abroun, Said. (1395). miR-4284 and miR-4484 as Putative Biomarkers for Diffuse Large B-Cell Lymphoma. سامانه مدیریت نشریات علمی, 41(4), 334-339.
Gholamhossein Tamaddon; Bita Geramizadeh; Mohammad Hossein Karimi; Seyed Javad Mowla; Said Abroun. "miR-4284 and miR-4484 as Putative Biomarkers for Diffuse Large B-Cell Lymphoma". سامانه مدیریت نشریات علمی, 41, 4, 1395, 334-339.
Tamaddon, Gholamhossein, Geramizadeh, Bita, Karimi, Mohammad Hossein, Mowla, Seyed Javad, Abroun, Said. (1395). 'miR-4284 and miR-4484 as Putative Biomarkers for Diffuse Large B-Cell Lymphoma', سامانه مدیریت نشریات علمی, 41(4), pp. 334-339.
Tamaddon, Gholamhossein, Geramizadeh, Bita, Karimi, Mohammad Hossein, Mowla, Seyed Javad, Abroun, Said. miR-4284 and miR-4484 as Putative Biomarkers for Diffuse Large B-Cell Lymphoma. سامانه مدیریت نشریات علمی, 1395; 41(4): 334-339.

miR-4284 and miR-4484 as Putative Biomarkers for Diffuse Large B-Cell Lymphoma

Iranian Journal of Medical Sciences
مقاله 11، دوره 41، شماره 4، مهر 2016، صفحه 334-339    اصل مقاله (902.19 K)
نوع مقاله: Brief Report(s)
نویسندگان
Gholamhossein Tamaddon1؛ Bita Geramizadeh2؛ Mohammad Hossein Karimi3؛ Seyed Javad Mowla4؛ Said Abroun* 1
1Department of Hematology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
2Department of Pathology, School of Medicine, Shiraz University of Medical Sciences,Shiraz,Iran
3Transplant Research Center, Nemazee Teaching Hospital, Shiraz University of Medical Sciences,Shiraz,Iran
4Department of Genetics, Faculty of Basic Sciences, Tarbiat Modares University, Tehran, Iran
چکیده
Diffuse large B-cell lymphoma is the most common type of non-Hodgkin lymphoma. MicroRNAs (miRNAs) are endogenous small RNA, which can regulate gene expression at the post-transcriptional level. MiRNA profiling has shown a great potential as novel diagnostic and prognostic biomarkers. The present study was performed at the Nemazee Teaching Hospital (Shiraz, Iran) from 2011 to 2013.The aim of this study was to assess the deregulation of miRNAs profiles in DLBL against hyperplasic reactive lymph node as a normal. This could serve as a biomarker for DLBL. The miRCURY LNATM microarray was used on the total RNA, which was extracted from formalin-fixed paraffin-embedded tissue of 24 de novo diffuse large B-cell lymphoma patients and 14 normal lymph nodes. The greatest changes were detected in miR-4284 and miR-4484 level in patient’s lymphoma samples. These miRNAs can act as a diagnostic biomarker for DLBL.
کلیدواژه‌ها
Lymphoma؛ Large B-Cell؛ Diffuse؛ MicroRNAs؛ Microarray Analysis
مراجع
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