Aqueous Extract of Anethum Graveolens L. has Potential Antioxidant and Antiglycation Effects | ||
| Iranian Journal of Medical Sciences | ||
| مقاله 10، دوره 41، شماره 4، 2016، صفحه 328-333 اصل مقاله (991.46 K) | ||
| نوع مقاله: Brief Report(s) | ||
| شناسه دیجیتال (DOI): 10.30476/ijms.2016.40370 | ||
| نویسندگان | ||
| Ebrahim Abbasi Oshaghi1؛ Iraj Khdadadi1؛ Heidar Tavilani1؛ Mohammad Taghi Goodarzi* 2 | ||
| 1Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran | ||
| 2Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; and Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran | ||
| چکیده | ||
| The aim of this study was to assess the antiglycation and antioxidant properties of aqueous extract of Anethum graveolens (dill). In the in vivo and in vitro experiments, antioxidant properties, blood glucose, and AGEs formation were determined. Dill extract was given orally to healthy and diabetic rats. Our results illustrated that different concentrations of dill extract (0.125, 0.25, 0.5, and 1 mg/ml) have potential antiradical and antioxidant activity. Aqueous extract of dill significantly reduced AGEs formation and fructosamine levels, protein carbonyl and also thiol group’s oxidation, amyloid cross-β and fragmentation. After 2 months, blood glucose levels (P=0.006) and AGEs formation (P=0.003) significantly reduced in dill treated group compared with untreated diabetic animals. In conclusion, dill can be recommended as herbal medicine for the control and prevention of diabetic complications. | ||
| کلیدواژهها | ||
| Anethum graveolens؛ Antioxidants؛ Herbal medicine؛ Hypoglycemic agents | ||
| مراجع | ||
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