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Karami, Ali, Khosravi, Mohamad Bagher, Shafa, Masih, Azemati, Simin, Khademi, Saeed, Akhlagh, Seyed Hedayatalla, Maghsodi, Behzad. (1395). Cardioprotective Effect of Extended Remote Ischemic Preconditioning in Patients Undergoing Coronary Artery Bypass Grafting: A Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 41(4), 265-274.
Ali Karami; Mohamad Bagher Khosravi; Masih Shafa; Simin Azemati; Saeed Khademi; Seyed Hedayatalla Akhlagh; Behzad Maghsodi. "Cardioprotective Effect of Extended Remote Ischemic Preconditioning in Patients Undergoing Coronary Artery Bypass Grafting: A Randomized Clinical Trial". سامانه مدیریت نشریات علمی, 41, 4, 1395, 265-274.
Karami, Ali, Khosravi, Mohamad Bagher, Shafa, Masih, Azemati, Simin, Khademi, Saeed, Akhlagh, Seyed Hedayatalla, Maghsodi, Behzad. (1395). 'Cardioprotective Effect of Extended Remote Ischemic Preconditioning in Patients Undergoing Coronary Artery Bypass Grafting: A Randomized Clinical Trial', سامانه مدیریت نشریات علمی, 41(4), pp. 265-274.
Karami, Ali, Khosravi, Mohamad Bagher, Shafa, Masih, Azemati, Simin, Khademi, Saeed, Akhlagh, Seyed Hedayatalla, Maghsodi, Behzad. Cardioprotective Effect of Extended Remote Ischemic Preconditioning in Patients Undergoing Coronary Artery Bypass Grafting: A Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 1395; 41(4): 265-274.

Cardioprotective Effect of Extended Remote Ischemic Preconditioning in Patients Undergoing Coronary Artery Bypass Grafting: A Randomized Clinical Trial

Iranian Journal of Medical Sciences
مقاله 2، دوره 41، شماره 4، مهر 2016، صفحه 265-274    اصل مقاله (391.26 K)
نوع مقاله: Original Article(s)
نویسندگان
Ali Karami1؛ Mohamad Bagher Khosravi2؛ Masih Shafa* 3؛ Simin Azemati2؛ Saeed Khademi2؛ Seyed Hedayatalla Akhlagh2؛ Behzad Maghsodi2
1Shiraz Anesthesiology and Critical Care Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
2Shiraz Anesthesiology and Critical Care Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran;
3Department of Cardiac Surgery, Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: The cardioprotective effect of ischemic preconditioning has been known for many years. Since the temporary ischemia in the heart may cause lethal cardiac effects, the idea of creating ischemia in organs far from the heart such as limbs was raised as remote ischemic preconditioning (RIPC). We hypothesized that the extension of RIPC has more cardioprotective effect in patients undergoing coronary artery bypass graft (CABG) surgeries.Methods: In this triple-blind randomized clinical trial study, 96 patients were randomly divided into 3 groups and two blood pressure cuffs were placed on both upper and lower extremities. In group A, only upper extremity cuff and in group B upper limb and lower limb cuff was inflated intermittently and group C was the control group. RIPC was induced with three 5-min cycles of cuff inflation about 100 mmHg over the initial systolic blood pressure before starting cardiopulmonary bypass. The primary endpoints were troponin I and creatine phosphokinasemyoglobin isoenzyme (CK-MB).Results: Six hours after the termination of CPB, there was a peak release of the troponin I level in all groups (group A=4.90 ng/ml, group B=4.40 ng/ml, and group C=4.50 ng/ml). There was a rise in plasma CK-MB in all groups postoperatively and there were not any significant differences in troponin I and CK-MB release between the three groups.Conclusion: RIPC induced by upper and lower limb ischemia does not reduce postoperative myocardial enzyme elevation in adult patients undergoing CABG.Trial Registration Number: IRCT2012071710311N1
کلیدواژه‌ها
Ischemic preconditioning؛ Coronary artery bypass؛ Troponin I
مراجع
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