Ameloblastomas are slow growing, locally invasive, benign odontogenic tumors of an epithelial origin, accounting for approximately 1% of all oral tumors. A 40-year-old man presented with a chief complaint of a swelling over the left side of his face of 4 years’ duration. On examination, gross facial asymmetry was detected, and a well-defined swelling was noted intraorally involving the left maxilla medially from the mid palatal raphe and obliterating the buccal vestibule laterally. The swelling was non-tender and exhibited dual consistencies: firm in the palate and cystic in the vestibular region. Computed tomography revealed a multilocular radiolucency, which involved the left maxilla, encroached into the left maxillary sinus and the nasal complex, and caused bony erosion. Early diagnosis and treatment are the key tools in managing ameloblastomas, failure of which may lead to a significant deterioration of the prognosis and an increased recurrence rate. Uncommon variants of ameloblastomas have been gaining interest recently. To date, 25 cases of hybrid ameloblastomas have been documented in the scientific literature. We present an extremely rare hybrid type of the ameloblastoma with combined follicular, cystic, acanthomatous, and desmoplastic variants, which render it the first of its kind to have ever been reported. |
- Gupta A, Jindal C. Hybrid ameloblastoma: report of a rare case and review of literature. International Journal of Oral and Maxillofacial Pathology. 2011;2:68-72.
- Gupta N, Anjum R, Gupta S, Lone P. Ameloblastoma of the Mandible: A Case Report with Review of Literature. Int J Head Neck Surg. 2012;3:56-8. doi: 0.5005/jp-journals-10001-1095.
- Effiom O, James O, Akeju O, Salami A, Odukoya O. Hybrid ameloblastoma in a nigerian: Report of a case and review of literature. OJST. 2013;3:347. doi: 10.4236/ojst.2013.37059.
- Oliveira LR, Matos F, Dominguete R, Zorgetto A, Ribeiro A. Ameloblastoma: report of two cases and a brief literature review. Int J Odontostomat. 2011;5:293-9. doi: 10.4067/S0718-381X2011000300014.
- Carvalho de Melo AU, de Farias Martorelli SB, Cavalcanti PH, Gueiros LA, Martorelli Fde O. Maxillary odontogenic myxoma involving the maxillary sinus: case report. Braz J Otorhinolaryngol. 2008;74:472-5. PubMed PMID: 18661026.
- Gade L, Patankar S, Khot K, Korde S, Alex S. Desmoplastic ameloblastoma of maxilla-A case report. J Clin Exp Dent. 2010;2:e204-6. doi: 10.4317/jced.2.e204.
- Kawai T, Kishino M, Hiranuma H, Sasai T, Ishida T. A unique case of desmoplastic ameloblastoma of the mandible: report of a case and brief review of the English language literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;87:258-63. doi: 10.1016/S1079-2104(99)70282-9. PubMed PMID: 10052385.
- Yamazaki M, Maruyama S, Abe T, Babkair H, Fujita H, Takagi R, et al. Hybrid ameloblastoma and adenomatoid odontogenic tumor: report of a case and review of hybrid variations in the literature. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;118:e12-e8. doi: 10.1016/j.oooo.2013.08.032.
- Wakoh M, Harada T, Inoue T. Follicular/desmoplastic hybrid ameloblastoma with radiographic features of concomitant fibro-osseous and solitary cystic lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;94:774-80. doi: 10.1067/moe.2002.129182. PubMed PMID: 12464906.
- Hirota M, Aoki S, Kawabe R, Fujita K. Desmoplastic ameloblastoma featuring basal cell ameloblastoma: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99:160-4. doi: 10.1016/j.tripleo.2004.05.020. PubMed PMID: 15660085.
- Desai H, Sood R, Shah R, Cawda J, Pandya H. Desmoplastic ameloblastoma: report of a unique case and review of literature. Indian J Dent Res. 2006;17:45-9. PubMed PMID: 16900895.
- Yazdi I, Seyedmajidi M, Foroughi R. Desmoplastic ameloblastoma (a hybrid variant): report of a case and review of the literature. Arch Iran Med. 2009;12:304-8. PubMed PMID: 19400611.
- Brooks JK, Al-Mubarak H, Ribera MJ, Cohen PD, Ross DS, Scheper MA. Diminutive, interradicular "hybrid" desmoplastic/acanthomatous ameloblastoma. Quintessence Int. 2010;41:209-12. PubMed PMID: 20213021.
- Angadi PV, Kale A, Hallikerimath S, Kotrashetti V, Mane D, Bhatt P, et al. 'Hybrid'desmoplastic ameloblastoma: an unusual case report with immunohistochemical investigation for TGF-[Beta] and review of literature. East J Med. 2011;16:9.-17.
- Rai R, Reddy SP, Shaik JA, Goyal S, Manjunath S, Sunda V, et al. Hybrid Lesion of Ameloblastoma: A Perplexing Pathological Entity. Journal of Oral Health and Dental Management. 2014;13:998-1003.
- dos Santos JN, De Souza VF, Azevedo RA, Sarmento VA, Souza LB. "Hybrid" lesion of desmoplastic and conventional ameloblastoma: immunohistochemical aspects. Braz J Otorhinolaryngol. 2006;72:709-13. doi: 10.1016/S1808-8694(15)31030-2. PubMed PMID: 17221066.
- Dandriyal R, Gupta A, Pant S, Baweja HH. Surgical management of ameloblastoma: Conservative or radical approach. Natl J Maxillofac Surg. 2011;2:22-7. doi: 10.4103/0975-5950.85849. PubMed PMID: 22442605; PubMed Central PMCID: PMC3304226.
- Seim P, Regezi JA, O'Ryan F. Hybrid ameloblastoma and calcifying epithelial odontogenic tumor: case report. J Oral Maxillofac Surg. 2005;63:852-5. doi: 10.1016/j.joms.2005.02.024. PubMed PMID: 15944987.
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