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Farzaneh, Mohamad, Shahryari, Jahanbanoo, Safaei, Akbar, Valibeigi, Behnaz, Karimi Davani, Shahrbanou, Tabibi, Narjes. (1395). Dicer Gene Expression as a Prognostic Factor in Acute Lymphoblastic Leukemia and Chronic Lymphocytic Leukemia in Fars Province. سامانه مدیریت نشریات علمی, 41(3), 223-229.
Mohamad Reza Farzaneh; Jahanbanoo Shahryari; Akbar Safaei; Behnaz Valibeigi; Shahrbanou Karimi Davani; Narjes Tabibi. "Dicer Gene Expression as a Prognostic Factor in Acute Lymphoblastic Leukemia and Chronic Lymphocytic Leukemia in Fars Province". سامانه مدیریت نشریات علمی, 41, 3, 1395, 223-229.
Farzaneh, Mohamad, Shahryari, Jahanbanoo, Safaei, Akbar, Valibeigi, Behnaz, Karimi Davani, Shahrbanou, Tabibi, Narjes. (1395). 'Dicer Gene Expression as a Prognostic Factor in Acute Lymphoblastic Leukemia and Chronic Lymphocytic Leukemia in Fars Province', سامانه مدیریت نشریات علمی, 41(3), pp. 223-229.
Farzaneh, Mohamad, Shahryari, Jahanbanoo, Safaei, Akbar, Valibeigi, Behnaz, Karimi Davani, Shahrbanou, Tabibi, Narjes. Dicer Gene Expression as a Prognostic Factor in Acute Lymphoblastic Leukemia and Chronic Lymphocytic Leukemia in Fars Province. سامانه مدیریت نشریات علمی, 1395; 41(3): 223-229.

Dicer Gene Expression as a Prognostic Factor in Acute Lymphoblastic Leukemia and Chronic Lymphocytic Leukemia in Fars Province

Iranian Journal of Medical Sciences
مقاله 8، دوره 41، شماره 3، مرداد 2016، صفحه 223-229    اصل مقاله (390.7 K)
نوع مقاله: Brief Report(s)
نویسندگان
Mohamad Reza Farzaneh* 1؛ Jahanbanoo Shahryari2؛ Akbar Safaei3؛ Behnaz Valibeigi3؛ Shahrbanou Karimi Davani4؛ Narjes Tabibi3
1Department of Pathology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
2Department of Pathology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
3Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
4Department of Biology, School of Sciences, University of Sistan and Baluchistan, Zahedan, Iran
چکیده
Alterations in the expression of microRNAs (miRNAs) have been proposed to play a role in the pathogenesis of acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL). Dicer is one of the main regulators of miRNA biogenesis, and deregulation of its expression has been indicated as a possible cause of miRNA alterations observed in various cancers. Our aim was to analyze the expression of the Dicer protein and its relationship with ALL and CLL. This cross-sectional study was performed from 2010 to 2012 in Shahid Faghihi Hospital, Shiraz, Iran. In this study, 30 patients with CLL, 21 patients with ALL, 10 child healthy donors, and 19 adult healthy donors were recruited. The patients’ samples were checked via flow cytometry, immunohistochemistry, and immunocytochemistry. The controls’ samples were also examined in the hematology ward. Total RNA was extracted from the bone marrow and peripheral blood samples of the patients and controls. Then, reverse-transcription polymerase chain reaction was used to estimate the level of Dicer miRNA. The outcomes of the expression analysis of Dicer revealed statistically significant differences between the ALL patients/child healthy controls (mean±SD, 0.19±0.28 vs. 0.73±0.12; P<0.001) and the CLL patients/adult healthy controls (mean±SD, 0.24±0.25 vs. 0.41±0.28; P=0.033). This is the first piece of evidence showing that the expression of the Dicer gene greatly decreased in the patients with ALL in comparison to the child controls. The expression of the Dicer gene was also downregulated in the patients with CLL  compared to the adult controls. Given the above findings, the expression of Dicer may play an important role in the progression and prognosis of these diseases.
کلیدواژه‌ها
DICER1 protein؛ Gene expression؛ Leukemia
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