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Roohi, A., Aghamohammadi, A., Shokri, F.. (1380). Association between Anti-IgA Antibody and Development of Adverse Reactions in Immunodeficient Patients Under Immunoglobulin Therapy. سامانه مدیریت نشریات علمی, 26(3-4), 90-94.
A. Roohi; A. Aghamohammadi; F. Shokri. "Association between Anti-IgA Antibody and Development of Adverse Reactions in Immunodeficient Patients Under Immunoglobulin Therapy". سامانه مدیریت نشریات علمی, 26, 3-4, 1380, 90-94.
Roohi, A., Aghamohammadi, A., Shokri, F.. (1380). 'Association between Anti-IgA Antibody and Development of Adverse Reactions in Immunodeficient Patients Under Immunoglobulin Therapy', سامانه مدیریت نشریات علمی, 26(3-4), pp. 90-94.
Roohi, A., Aghamohammadi, A., Shokri, F.. Association between Anti-IgA Antibody and Development of Adverse Reactions in Immunodeficient Patients Under Immunoglobulin Therapy. سامانه مدیریت نشریات علمی, 1380; 26(3-4): 90-94.

Association between Anti-IgA Antibody and Development of Adverse Reactions in Immunodeficient Patients Under Immunoglobulin Therapy

Iranian Journal of Medical Sciences
مقاله 1، دوره 26، 3-4، اسفند 2001، صفحه 90-94    اصل مقاله (985.69 K)
نوع مقاله: Original Article(s)
نویسندگان
A. Roohi* ؛ A. Aghamohammadi؛ F. Shokri
چکیده
Background: Mild to severe post-transfusion adverse reactions have been reported in a proportion of immunodeficient patients receiving intravenous immunoglobulin (IVIg). Anti-IgA antibody has been proposed to be associated with development of such reactions. Objective: To assess the association between anti-IgA levels of different isotypes and adverse reactions induced in immunodeficient patients following infusion of IVIg. Methods: In this study, IgM, IgG and IgE anti-IgA antibodies were measured by an indirect ELISA method in serum samples from 31 patients with a variety of immunodeficiencies receiving IVIg and 24 normal individuals.Results: Anti-IgA antibody of all three isotypes were detectable in all sera. However, when presented as proportion of total IgA (anti –IgA/total IgA)IgG, IgE isotypes are significantly higher in patients with adverse reactions compared to those without reactions or normal subjects.Conclusion: Both IgG and IgE anti-IgA antibodies may contribute to the development and severity of adverse reactions in some patients receiving IVIg.
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