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Motaghinejad, Majid, Sadeghi-Hashjin, Goudarz, Koohi, Mohammad Kazem, Karimian, Seyed Morteza. (1394). Attenuation of Withdrawal Signs, Blood Cortisol, and Glucose Level with Various Dosage Regimens of Morphine after Precipitated Withdrawal Syndrome in Mice. سامانه مدیریت نشریات علمی, 41(1), 53-58.
Majid Motaghinejad; Goudarz Sadeghi-Hashjin; Mohammad Kazem Koohi; Seyed Morteza Karimian. "Attenuation of Withdrawal Signs, Blood Cortisol, and Glucose Level with Various Dosage Regimens of Morphine after Precipitated Withdrawal Syndrome in Mice". سامانه مدیریت نشریات علمی, 41, 1, 1394, 53-58.
Motaghinejad, Majid, Sadeghi-Hashjin, Goudarz, Koohi, Mohammad Kazem, Karimian, Seyed Morteza. (1394). 'Attenuation of Withdrawal Signs, Blood Cortisol, and Glucose Level with Various Dosage Regimens of Morphine after Precipitated Withdrawal Syndrome in Mice', سامانه مدیریت نشریات علمی, 41(1), pp. 53-58.
Motaghinejad, Majid, Sadeghi-Hashjin, Goudarz, Koohi, Mohammad Kazem, Karimian, Seyed Morteza. Attenuation of Withdrawal Signs, Blood Cortisol, and Glucose Level with Various Dosage Regimens of Morphine after Precipitated Withdrawal Syndrome in Mice. سامانه مدیریت نشریات علمی, 1394; 41(1): 53-58.

Attenuation of Withdrawal Signs, Blood Cortisol, and Glucose Level with Various Dosage Regimens of Morphine after Precipitated Withdrawal Syndrome in Mice

Iranian Journal of Medical Sciences
مقاله 9، دوره 41، شماره 1، فروردین 2016، صفحه 53-58    اصل مقاله (1.18 M)
نوع مقاله: Brief Report(s)
نویسندگان
Majid Motaghinejad* 1؛ Goudarz Sadeghi-Hashjin2؛ Mohammad Kazem Koohi2؛ Seyed Morteza Karimian3
1Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
2Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
3Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Morphine withdrawal usually results in unsuccessful outcomes. Despite partial benefits from alternative substances such as methadone, its use may not lead to the desired result due to the lack of mental tranquility during the withdrawal period. In this study, by means of an animal model, morphine itself was used to manage morphine dependence. Forty mice were divided into 5 groups, in which 4 groups became dependent by increasing daily doses of morphine for 7 days (15-45 mg/kg). Afterwards, the animals received morphine for 14 days by either of the following regimens:Once daily 45 mg/kg (positive controls)Increasing the interval (each time 6 hours longer than the previous interval)Irregular interval in every 36, 12 and 24 hours until the 21th day12, 24, 36 hours decreasing doses (each time 2.5 mg/kg less than the former dosage)Negative controls received saline solution only. On day 22, total withdrawal index (TWI) was determined by injecting 3 mg/kg of naloxone. Thereafter, blood samples were taken for the measurement of cortisol and glucose levels. TWI significantly decreased in all test groups in comparison with the positive control animals (P<0.001). Cortisol levels significantly decreased when either the dosage or the administration frequencies were decreased on a regular and gradual basis (P<0.005). Blood glucose levels significantly decreased in animals that received decreasing doses of morphine (P<0.005). This study suggests that no other measures may be required in clinical practice except for changing the dosage regimen of morphine for the cessation of self-administration.
کلیدواژه‌ها
Morphine؛ Cortisol؛ Glucose؛ Substance-Related Disorders؛ Withdrawal syndrome
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