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Salah, Samia, El-Masry, Sahar, Sheba, Hala, El Banna, Rokia, Saad, Walaa. (1394). Bone Mineral Density in Egyptian Children with Familial Mediterranean Fever. سامانه مدیریت نشریات علمی, 41(1), 2-8.
Samia Salah; Sahar A El-Masry; Hala Fathy Sheba; Rokia El Banna; Walaa Saad. "Bone Mineral Density in Egyptian Children with Familial Mediterranean Fever". سامانه مدیریت نشریات علمی, 41, 1, 1394, 2-8.
Salah, Samia, El-Masry, Sahar, Sheba, Hala, El Banna, Rokia, Saad, Walaa. (1394). 'Bone Mineral Density in Egyptian Children with Familial Mediterranean Fever', سامانه مدیریت نشریات علمی, 41(1), pp. 2-8.
Salah, Samia, El-Masry, Sahar, Sheba, Hala, El Banna, Rokia, Saad, Walaa. Bone Mineral Density in Egyptian Children with Familial Mediterranean Fever. سامانه مدیریت نشریات علمی, 1394; 41(1): 2-8.

Bone Mineral Density in Egyptian Children with Familial Mediterranean Fever

Iranian Journal of Medical Sciences
مقاله 1، دوره 41، شماره 1، فروردین 2016، صفحه 2-8    اصل مقاله (308.79 K)
نوع مقاله: Original Article(s)
نویسندگان
Samia Salah1؛ Sahar A El-Masry* 2؛ Hala Fathy Sheba3؛ Rokia El Banna2؛ Walaa Saad2
1Rheumatology Department, Abo El-Rish Children Hospital, Cairo University, Giza, Egypt
2Biological Anthropology Department, Medical Research Division, National Research Centre, Giza, Egypt
3Clinical Pathology Department, Kasr El-Aini Hospital, Cairo University, Giza, Egypt
چکیده
Background: Familial Mediterranean fever (FMF) has episodic or subclinical inflammation that may lead to a decrease in bone mineral density (BMD). The objective of this study was to assess BMD in Egyptian children with FMF on genetic basis.Methods: A cross sectional study included 45 FMF patients and 25 control children of both sexes in the age range between 3-16 years old. The patients were reclassified into two groups, namely group I(A) with 23 cases using colchicine for 1 month or less, and group I(B) with 22 cases using colchicine for more than 6 months. For both the patients and control groups, MEFV mutations were defined using molecular genetics technique and BMD was measured by DXA at the proximal femur and lumbar spines.Results: Four frequent gene mutations were found in the patient group E148Q (35.6%), V726A (33.3%), M680I (28.9%), and M694V (2.2%). There were also four heterozygous gene mutations in 40% of the control children. Patients receiving colchicine treatment for less than 1 month had highly significant lower values of BMD at the femur and lumbar spines than the control children (P=0.007, p <0.001). Patients receiving colchicine treatment for more than 6 months had improved values of BMD at femur compared with the control, but there were still significant differences between them in lumbar spine (P=0.036). There were insignificant effect of gene mutation type on BMD and the risk of osteopenia among the patients.Conclusion: FMF had a significant effect on BMD. However, regular use of colchicine treatment improves this effect mainly at the femur.
کلیدواژه‌ها
Familial mediterranean fever؛ Bone density؛ Genes؛ Children
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