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Hooman, N., Otoukesh, H., Safaii, H., Mehrazma, M., Yousefi, S.. (1394). Quantification of Proteinuria with Urinary Protein to Osmolality Ratios in Children. سامانه مدیریت نشریات علمی, 29(4), 168-171.
N. Hooman; H. Otoukesh; H. Safaii; M. Mehrazma; S. Yousefi. "Quantification of Proteinuria with Urinary Protein to Osmolality Ratios in Children". سامانه مدیریت نشریات علمی, 29, 4, 1394, 168-171.
Hooman, N., Otoukesh, H., Safaii, H., Mehrazma, M., Yousefi, S.. (1394). 'Quantification of Proteinuria with Urinary Protein to Osmolality Ratios in Children', سامانه مدیریت نشریات علمی, 29(4), pp. 168-171.
Hooman, N., Otoukesh, H., Safaii, H., Mehrazma, M., Yousefi, S.. Quantification of Proteinuria with Urinary Protein to Osmolality Ratios in Children. سامانه مدیریت نشریات علمی, 1394; 29(4): 168-171.

Quantification of Proteinuria with Urinary Protein to Osmolality Ratios in Children

Iranian Journal of Medical Sciences
مقاله 4، دوره 29، شماره 4، دی 2004، صفحه 168-171    اصل مقاله (199.09 K)
نوع مقاله: Original Article(s)
نویسندگان
N. Hooman* 1؛ H. Otoukesh1؛ H. Safaii1؛ M. Mehrazma2؛ S. Yousefi2
1Departments of pediatric nephrology Iran University of medical sciences, Tehran, Iran
2Departments of Pathology, Ali Asgar children hospital, Iran University of medical sciences, Tehran, Iran
چکیده
Background: The ratio of urine protein to urine osmolality has recently been suggested as an accurate method to determine proteinuria.  Objective: We studied the correlation of urine protein to urine osmolality ratio with 24-hr urinary protein excretion. Methods: 150 children aged 0.11–17 years admitted to the Department of Pediatric Nephrology were included in this study. Early morning urine samples and 24-hr urine specimens were collected and analyzed for protein, creatinine, and osmolality. The patients with chronic renal failure were not excluded. Two groups were established: Children with no proteinuria (group 1) and those with proteinuria (group 2).  Results: The optimal cutoff value of abnormal proteinuria and nephrotic range proteinuria was determined to be a protein–osmolality ratio (Up/Uosm) 0.27 and 1.59 mg/l/mOsm respectively. The correlation of 24-hr urinary protein excretion with both urinary protein/creatinine ratio (Up/Ucr) and Up/Uosm was highly significant (p<0.001). According to the receiver operator characteristic (ROC) curves analysis, we found no differences between Up/Uosm and Up/Ucr ratios in detecting either abnormal proteinuria or nephrotic syndrome.  Conclusion: Urine protein to urine osmolality ratio seems to be a simple and a valuable test for the assessment of the degree of proteinuria in children.
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