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Fallahzadeh, M.H., Noorafshan, A., Tanideh, N., Badeli, H.R., Bazargani, A.. (1394). Effects of Betamethasone and Gentamicin on Renal Scarring Induced by Mannose-Sensitive E Coli Pyelonephritis in Rat. سامانه مدیریت نشریات علمی, 29(3), 130-133.
M.H. Fallahzadeh; A. Noorafshan; N. Tanideh; H.R. Badeli; A. Bazargani. "Effects of Betamethasone and Gentamicin on Renal Scarring Induced by Mannose-Sensitive E Coli Pyelonephritis in Rat". سامانه مدیریت نشریات علمی, 29, 3, 1394, 130-133.
Fallahzadeh, M.H., Noorafshan, A., Tanideh, N., Badeli, H.R., Bazargani, A.. (1394). 'Effects of Betamethasone and Gentamicin on Renal Scarring Induced by Mannose-Sensitive E Coli Pyelonephritis in Rat', سامانه مدیریت نشریات علمی, 29(3), pp. 130-133.
Fallahzadeh, M.H., Noorafshan, A., Tanideh, N., Badeli, H.R., Bazargani, A.. Effects of Betamethasone and Gentamicin on Renal Scarring Induced by Mannose-Sensitive E Coli Pyelonephritis in Rat. سامانه مدیریت نشریات علمی, 1394; 29(3): 130-133.

Effects of Betamethasone and Gentamicin on Renal Scarring Induced by Mannose-Sensitive E Coli Pyelonephritis in Rat

Iranian Journal of Medical Sciences
مقاله 7، دوره 29، شماره 3، دی 2004، صفحه 130-133    اصل مقاله (179.25 K)
نوع مقاله: Original Article(s)
نویسندگان
M.H. Fallahzadeh* 1؛ A. Noorafshan2؛ N. Tanideh3؛ H.R. Badeli1؛ A. Bazargani4
1Department of Pediatrics, Shiraz University of Medical Sciences Shiraz, Iran
2Department of Anatomy, Shiraz University of Medical Sciences Shiraz, Iran
3Department of Pharmacology Shiraz University of Medical Sciences Shiraz, Iran
4Department of Microbiology Shiraz University of Medical Sciences Shiraz, Iran
چکیده
Background: Pyelonephritis can lead to renal scar. Objective: To evaluate the effects of betamethasone in preventing renal scarring in rat model of pyelonephritis. Methods: Sixty three female Sprague-Dawley rats were divided into seven groups. Group A was the control. Mannose-sensitive E coli was directly inoculated into the left kidney exposed under general anesthesia in groups C–G. Group B received normal saline. Two days after bacterial inoculation, groups C, E and F received gentamicin for 10 days. Betamethasone was injected for three days to animals in groups of D, E (2 days after bacterial inoculation) and F (5 days after bacterial inoculation). Group G received no treatment. Eight weeks after bacterial inoculation, animals were sacrificed and the volume (amount) of renal scar was determined using the stereological techniques. Results: Changes in the weight and volume of the kidneys were not statistically significant. No scar was detected in group A, but all other groups including group B with intrarenal injections showed scarring. The volume density and absolute volume of the scar in groups C–G were significantly more than group B (p<0.001), whereas they did not differ significantly from each other. Conclusion: Betamethasone and/or gentamicin, when used two days after induction of pyelonephritis were not effective in preventing renal scar.
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