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The Efficacy of Implant of Octacalcium Phos-phate in Combination with Bone Matrix Gelatin on Bone Regeneration in Skull Defects in Rat | ||
| Iranian Journal of Medical Sciences | ||
| مقاله 6، دوره 29، شماره 3، دی 2004، صفحه 124-129 اصل مقاله (255.35 K) | ||
| نوع مقاله: Original Article(s) | ||
| نویسندگان | ||
| F. Sargolzaei-Aval* 1؛ A. Sobhani2؛ M.R. Arab1؛ S.A . Sarani1؛ M.H. Heydari3 | ||
| 1Departments of Anatomy, Zahedan University of Medical Sciences, Zahedan, Iran. | ||
| 2Departments of Anatomy, Tehran University of Medical Sciences, Tehran, Iran. | ||
| 3Fasa Faculty of Medical Sciences, Fasa, Iran. | ||
| چکیده | ||
| Background: In several conditions we have face cranial bone defects. Reconstruction of these defects remains one of the most challenging problems encountered by craniofacial surgeons. Objective: To evaluate bone repair in cranial bone defects by use of an implant made of octacalcium phosphate in combination with bone matrix gelatin (OCP/BMG). Methods: We used 40, 5–6-week-old male Sprague-Dawley rats. A full thickness standardized trephine defect—5-mm in diameter—was made in the rat parietal bone and OCP/BMG was implanted into the defect. No OCP/BMG particles were implanted in control group that was otherwise treated identically. After sacrificing the rats chronologically and processing the tissues by routine histological procedures, 5-mm thick sections of bone were stained and examined under light microscope. Results: On the 5th day of implantation, inflammatory cells were seen around the implanted materials, especially around the OCP particles. By the end of 21st day, almost all of the OCP/BMG particles were absorbed and bone trabeculae, bone marrow cavities and bone marrow tissues were seen. In the control group, at the end of 21th day, a few areas of new bone were seen near to the defect margins and host bone, however, in much less amount than in the experimental group. Conclusion: Implant of OCP/BMG appears to stimulate new bone regeneration in bone defects. These biomaterials can be used for repair of cranial bone defects. | ||
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