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Zahedmehr, A., Delmaghani, S., Sharifian, R., Lak, M., Zeinali, S.. (1394). The Frequencies of three Factor IX-Linked Restriction Fragment Length Polymorphisms in Iranian Patients with Hemophilia B. سامانه مدیریت نشریات علمی, 29(1), 26-30.
A. Zahedmehr; S. Delmaghani; R. Sharifian; M. Lak; S. Zeinali. "The Frequencies of three Factor IX-Linked Restriction Fragment Length Polymorphisms in Iranian Patients with Hemophilia B". سامانه مدیریت نشریات علمی, 29, 1, 1394, 26-30.
Zahedmehr, A., Delmaghani, S., Sharifian, R., Lak, M., Zeinali, S.. (1394). 'The Frequencies of three Factor IX-Linked Restriction Fragment Length Polymorphisms in Iranian Patients with Hemophilia B', سامانه مدیریت نشریات علمی, 29(1), pp. 26-30.
Zahedmehr, A., Delmaghani, S., Sharifian, R., Lak, M., Zeinali, S.. The Frequencies of three Factor IX-Linked Restriction Fragment Length Polymorphisms in Iranian Patients with Hemophilia B. سامانه مدیریت نشریات علمی, 1394; 29(1): 26-30.

The Frequencies of three Factor IX-Linked Restriction Fragment Length Polymorphisms in Iranian Patients with Hemophilia B

Iranian Journal of Medical Sciences
مقاله 6، دوره 29، شماره 1، دی 2004، صفحه 26-30    اصل مقاله (179.31 K)
نوع مقاله: Original Article(s)
نویسندگان
A. Zahedmehr1؛ S. Delmaghani1؛ R. Sharifian2؛ M. Lak2؛ S. Zeinali* 1
1Department of Biotechnology, Pas-teur Institute of Iran, Tehran, Iran
2Hemophilia Centre, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Background: Hemophilia B is an X-linked recessive coagulation disorder caused by factor IX deficiency.  Analysis of factor IX gene polymorphisms is considered the best approach for prenatal diagnosis and carrier detection of hemophilia B where the identification of gene mutation is not easily possible. Objective: To study the frequency of three factor IX-linked restriction fragment length polymorphisms (RFLPs) in Iranian women. Methods: 50 normal women and 50 mothers of patients with hemophilia B entered this study. RFLP/Polymerase chain reaction (PCR) techniques for detection of BamHI, HhaI and MnlI sites were used.Results: The frequencies of DNA polymorphisms were 0.50/0.50 for HhaI; 0.24/0.76 for MnlI; and 0.02/0.98 for BamHI sites.  Among 9 different haplotypes, 2 major haplotypes were predominated. Conclusion: HhaI and MnlI RFLPs can be used for carrier detection and prenatal diagnosis of hemophilia B. 
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