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Shid Moosavi, S.M., Barmaki, B., Geramizadeh, B., Fallahzadeh, H., Johns, E. J.. (1394). Effect of Endothelin-A Receptor Blockade on the Early Phase of Ischemia/Reperfusion-Induced Acute Renal Failure in Anesthetized Rats. سامانه مدیریت نشریات علمی, 29(1), 14-20.
S.M. Shid Moosavi; B. Barmaki; B. Geramizadeh; H. Fallahzadeh; E. J. Johns. "Effect of Endothelin-A Receptor Blockade on the Early Phase of Ischemia/Reperfusion-Induced Acute Renal Failure in Anesthetized Rats". سامانه مدیریت نشریات علمی, 29, 1, 1394, 14-20.
Shid Moosavi, S.M., Barmaki, B., Geramizadeh, B., Fallahzadeh, H., Johns, E. J.. (1394). 'Effect of Endothelin-A Receptor Blockade on the Early Phase of Ischemia/Reperfusion-Induced Acute Renal Failure in Anesthetized Rats', سامانه مدیریت نشریات علمی, 29(1), pp. 14-20.
Shid Moosavi, S.M., Barmaki, B., Geramizadeh, B., Fallahzadeh, H., Johns, E. J.. Effect of Endothelin-A Receptor Blockade on the Early Phase of Ischemia/Reperfusion-Induced Acute Renal Failure in Anesthetized Rats. سامانه مدیریت نشریات علمی, 1394; 29(1): 14-20.

Effect of Endothelin-A Receptor Blockade on the Early Phase of Ischemia/Reperfusion-Induced Acute Renal Failure in Anesthetized Rats

Iranian Journal of Medical Sciences
مقاله 4، دوره 29، شماره 1، دی 2004، صفحه 14-20    اصل مقاله (167.65 K)
نوع مقاله: Original Article(s)
نویسندگان
S.M. Shid Moosavi* 1؛ B. Barmaki1؛ B. Geramizadeh2؛ H. Fallahzadeh3؛ E. J. Johns4
1Department of Physiology, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Pathology, Medical School, Shiraz University of Medi-cal Sciences, Shiraz, Iran
3Department of Pediatrics, Nephrol-ogy Section, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
4Deparment of Physiology, University College Cork, Ireland
چکیده
Background: Previous studies have shown increases in endothelin (ET) concentration of plasma and renal tissues in acute renal failure (ARF).  ET has a potent vasoconstrictor effect, through binding with its ETA receptors, and may play some roles in renal hemodynamic dysfunction in ARF.Objective: To examine the beneficial effect of a selective ETA-receptor antagonist on renal dysfunction and tissue damage occurring during the early phase of ischemia/reperfusion-induced ARF.Methods: Pentobarbital anesthetized rats were prepared for the measurement of blood pressure and renal function. A 0.5 hr clearance period was taken as control period, followed by 1 hr, and then a 4 hr experimental clearance period was taken. In ischemia/reperfusion (I/R) group, 30 min after the end of the control clearance period, renal ischemia was induced by bilateral renal artery clamping for 30 min. In drug-treated (I/R+D) group, a selective ETA-receptor antagonist (UK-350,926) was infused iv at 50 mg/kg/min for 30 min before and 2 hr following occlusion of renal arteries. There was also a sham-operated group.Results: In I/R group, renal ischemia lowered creatinine clearance (CCr) by 76% (p<0.001), but elevated urine flow rate (V­0) by 2.9-fold (p<0.01) and absolute Na+excretion (UNaV0) by 3.2-fold (p<0.05) during the 4 hr reperfusion period as compared to their own control values. In I/R+D group, V0 and UNaV0 did not change significantly during the 4 hr experimental period, but the amount of decrease in CCr was equal to that of I/R group. Histological examination showed a mild degree of tissue damage in the cortex of I/R group but not in I/R+D and sham groups.Conclusion: Administration of the ETA-receptor antagonist does not prevent the fall of glomerular filtration, but it does ameliorate the damage of renal tissue and tubular reabsorption of Na­+ and water during 4 hrs of reperfusion following the ischemic challenge.
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