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The Efficacy of Oral Erythromycin in Enhancement of Milk Tolerance in Premature Infants: A Randomized Clinical Trial | ||
| Iranian Journal of Medical Sciences | ||
| مقاله 1، دوره 29، شماره 1، دی 2004، صفحه 1-4 اصل مقاله (59.57 K) | ||
| نوع مقاله: Original Article(s) | ||
| نویسندگان | ||
| A. Madani* ؛ N. Pishva؛ Sh. Pourarian؛ M. Zarkesh | ||
| Neonatology Section, Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| چکیده | ||
| Background: A great number of premature neonates do not tolerate sufficient milk during the early neonatal period. Objective: To evaluate the effect of oral erythromycin on enhancement of feeding tolerance in preterm newborns. Methods: Sixty preterm neonates intolerant to milk of >75 ml/kg/day during 5 days after the start of feedings, were randomized into a treatment and a control groups. Oral erythromycin (12.5 mg/kg/dose) was given to the treatment group for a maximum of 10 days, or until full enteral feeding (150 ml/kg/day) was tolerated. Results: Oral erythromycin enhanced feeding tolerance in premature neonates of ≥32 wks of gestation (p<0.032) with no adverse effects and led to a shorter hospital stay (p<0.003) as compared to the control group. Conclusion: Oral erythromycin is an effective drug for alleviating feeding intolerance in preterms. | ||
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