LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,089
تعداد مقالات9,995
تعداد مشاهده مقاله26,558,942
تعداد دریافت فایل اصل مقاله7,307,187
Behzad-Behbahani, A., Mafi-Nejad, A., Tabei, S.Z., Lankarani, K.B., Rashidi, M., Rasouli, M., Pourabbas, B., Torab, A., Salah, A.R.. (1383). Indication of Anti-HBc Antibody Screening and HBV-DNA Detection in Diagnosing Latent Hepatitis B Virus Infection. سامانه مدیریت نشریات علمی, 30(1), 28-33.
A. Behzad-Behbahani; A. Mafi-Nejad; S.Z. Tabei; K.B. Lankarani; M. Rashidi; M. Rasouli; B. Pourabbas; A. Torab; A.R. Salah. "Indication of Anti-HBc Antibody Screening and HBV-DNA Detection in Diagnosing Latent Hepatitis B Virus Infection". سامانه مدیریت نشریات علمی, 30, 1, 1383, 28-33.
Behzad-Behbahani, A., Mafi-Nejad, A., Tabei, S.Z., Lankarani, K.B., Rashidi, M., Rasouli, M., Pourabbas, B., Torab, A., Salah, A.R.. (1383). 'Indication of Anti-HBc Antibody Screening and HBV-DNA Detection in Diagnosing Latent Hepatitis B Virus Infection', سامانه مدیریت نشریات علمی, 30(1), pp. 28-33.
Behzad-Behbahani, A., Mafi-Nejad, A., Tabei, S.Z., Lankarani, K.B., Rashidi, M., Rasouli, M., Pourabbas, B., Torab, A., Salah, A.R.. Indication of Anti-HBc Antibody Screening and HBV-DNA Detection in Diagnosing Latent Hepatitis B Virus Infection. سامانه مدیریت نشریات علمی, 1383; 30(1): 28-33.

Indication of Anti-HBc Antibody Screening and HBV-DNA Detection in Diagnosing Latent Hepatitis B Virus Infection

Iranian Journal of Medical Sciences
مقاله 7، دوره 30، شماره 1، خرداد 2005، صفحه 28-33    اصل مقاله (100.21 K)
نوع مقاله: Original Article(s)
نویسندگان
A. Behzad-Behbahani* ؛ A. Mafi-Nejad؛ S.Z. Tabei؛ K.B. Lankarani؛ M. Rashidi؛ M. Rasouli؛ B. Pourabbas؛ A. Torab؛ A.R. Salah
چکیده
Background: In spite of available, and sensitive screening assay for detection of hepatitis B virus surface antigen (HBsAg), occasional cases of post-transfusion hepatitis B virus infection are still observed. The aim of the present study was to assess the prevalence of positive anti hepatitis B core (anti-HBc) and presence of HBV-DNA in serum sample of healthy blood donors negative for both HBsAg and anti-HCV antibody. We evaluated whether anti-HBc could be adopted as a screening assay for blood donation. Material and Methods: Two thousands sera negative for both HBsAg and anti-HCV collected from healthy blood donors tested for presence of anti-HBc antibody. All sera positive for anti-HBc antibody were then investigated for determination of anti-HBc and anti-HBs titers, HbeAg and anti-HBe antibody by enzyme immunoassay (EIA). Every sample that tested negative for HBsAg but positive for anti-HBc alone or in combination with other serological markers was also examined for the presence of HBV-DNA by polymerase chain reaction (PCR). Results: Out of 2000 HBsAg negative blood samples, 131 samples (6.55%) were positive for anti-HBc. HBV-DNA was detected in 16 of 131(12.2%) anti-HBc positive specimens. The liver function test results were all in normal range except in 4 (25%) of 16 HBV-DNA positive subjects. Conclusion: Anti-HBc antibody should be tested routinely on blood donor volunteers, and if the sera become positive regardless of anti-HBs titer, the blood should be discarded. Further testing for HBV-DNA is appropriate to follow up the blood donor patient for HBV infection.Iran J Med Sci 2005; 30(1): 28-33. Keywords ● hepatitis B virus infection ● blood donors ● Iran ● anti-HBc ● HBV-DNA
آمار
تعداد مشاهده مقاله: 1,926
تعداد دریافت فایل اصل مقاله: 725


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب