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Alavi, Samin, Arabi, Nahid, Kaji Yazdi, Mohammad, Arzanian, Mohammad Taghi, Zohrehbandian, Farahnaz. (1394). Hereditary Spherocytosis Unmasked by Human Parvovirus B19 Induced Aplastic Crisis in a Family. سامانه مدیریت نشریات علمی, 40(5), 461-464.
Samin Alavi; Nahid Arabi; Mohammad Kaji Yazdi; Mohammad Taghi Arzanian; Farahnaz Zohrehbandian. "Hereditary Spherocytosis Unmasked by Human Parvovirus B19 Induced Aplastic Crisis in a Family". سامانه مدیریت نشریات علمی, 40, 5, 1394, 461-464.
Alavi, Samin, Arabi, Nahid, Kaji Yazdi, Mohammad, Arzanian, Mohammad Taghi, Zohrehbandian, Farahnaz. (1394). 'Hereditary Spherocytosis Unmasked by Human Parvovirus B19 Induced Aplastic Crisis in a Family', سامانه مدیریت نشریات علمی, 40(5), pp. 461-464.
Alavi, Samin, Arabi, Nahid, Kaji Yazdi, Mohammad, Arzanian, Mohammad Taghi, Zohrehbandian, Farahnaz. Hereditary Spherocytosis Unmasked by Human Parvovirus B19 Induced Aplastic Crisis in a Family. سامانه مدیریت نشریات علمی, 1394; 40(5): 461-464.

Hereditary Spherocytosis Unmasked by Human Parvovirus B19 Induced Aplastic Crisis in a Family

Iranian Journal of Medical Sciences
مقاله 11، دوره 40، شماره 5، آذر 2015، صفحه 461-464    اصل مقاله (405.31 K)
نوع مقاله: Case Report(s)
نویسندگان
Samin Alavi* 1؛ Nahid Arabi1؛ Mohammad Kaji Yazdi2؛ Mohammad Taghi Arzanian1؛ Farahnaz Zohrehbandian3
1Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iranii
3Islamic azad university, North branch
چکیده
Human parvovirus (HPV) B19 induced aplastic crisis in a family leading to the diagnosis of hereditary spherocytosis (HS) is a very rare condition being barely reported in the literature. We herein report a 4-year-old girl, her brother, and their mother who all presented with progressive pallor and jaundice after a febrile illness. The HPV B19 was diagnosed using polymerase chain reaction (PCR) and positive serology for specific anti-HPV B19 IgM. They were further diagnosed with having HS. The clinical importance of this report is that in the case of an abrupt onset of unexplained severe anemia and jaundice, one should consider underlying hemolytic anemias mostly hereditary spherocytosis complicated by HPV B19 aplastic crisis. Herein, we report the occurrence of this condition, simultaneously in three members of a family. The distinguished feature of this report is that all affected family members developed some degrees of transient pancytopenia, not only anemia, all simultaneously in the course of their disease.
کلیدواژه‌ها
Hereditary spherocytosis؛ Parvovirus B19؛ Pancytopenia
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