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Rezaei Farimani, Azam, Saidijam, Massoud, Goodarzi, Mohammad Taghi, Yadegar azari, Reza, Asadi, Soheila, Zarei, Sadegh, Shabab, Nooshin. (1394). Effect of Resveratrol Supplementation on the SNARE Proteins Expression in Adipose Tissue of Stroptozotocin-Nicotinamide Induced Type 2 Diabetic Rats. سامانه مدیریت نشریات علمی, 40(3), 248-255.
Azam Rezaei Farimani; Massoud Saidijam; Mohammad Taghi Goodarzi; Reza Yadegar azari; Soheila Asadi; Sadegh Zarei; Nooshin Shabab. "Effect of Resveratrol Supplementation on the SNARE Proteins Expression in Adipose Tissue of Stroptozotocin-Nicotinamide Induced Type 2 Diabetic Rats". سامانه مدیریت نشریات علمی, 40, 3, 1394, 248-255.
Rezaei Farimani, Azam, Saidijam, Massoud, Goodarzi, Mohammad Taghi, Yadegar azari, Reza, Asadi, Soheila, Zarei, Sadegh, Shabab, Nooshin. (1394). 'Effect of Resveratrol Supplementation on the SNARE Proteins Expression in Adipose Tissue of Stroptozotocin-Nicotinamide Induced Type 2 Diabetic Rats', سامانه مدیریت نشریات علمی, 40(3), pp. 248-255.
Rezaei Farimani, Azam, Saidijam, Massoud, Goodarzi, Mohammad Taghi, Yadegar azari, Reza, Asadi, Soheila, Zarei, Sadegh, Shabab, Nooshin. Effect of Resveratrol Supplementation on the SNARE Proteins Expression in Adipose Tissue of Stroptozotocin-Nicotinamide Induced Type 2 Diabetic Rats. سامانه مدیریت نشریات علمی, 1394; 40(3): 248-255.

Effect of Resveratrol Supplementation on the SNARE Proteins Expression in Adipose Tissue of Stroptozotocin-Nicotinamide Induced Type 2 Diabetic Rats

Iranian Journal of Medical Sciences
مقاله 8، دوره 40، شماره 3، مرداد 2015، صفحه 248-255    اصل مقاله (297.77 K)
نوع مقاله: Original Article(s)
نویسندگان
Azam Rezaei Farimani1؛ Massoud Saidijam2؛ Mohammad Taghi Goodarzi* 2؛ Reza Yadegar azari3؛ Soheila Asadi1؛ Sadegh Zarei1؛ Nooshin Shabab3
1Department of Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan Iran
3Department of Genetic and Molecular Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
چکیده
Background: Glucose uptake by muscles and fat cells is carried out by the GLUT4 system. Isoforms of the SNAP23, syntaxin-4 and VAMP-2 play an important role in regulating GLUT-4 trafficking and fusion in adipocytes. The changes of SNARE proteins levels and thus impaired GLUT-4 displacement can be one of the etiological causes of type 2 diabetes.Due to changes in the expression of these proteins in diabetes, the aim of this study was to investigate the effect of the natural compound resveratrol with anti-diabetic properties on impaired expression of SNARE proteins in type 2 diabetes.Methods: Forty male Wistar rats were used in this study. Type 2 diabetes was induced by administering a single dose of streptozotocin and nicotinamide. The expression of SNAP-23, syntaxin-4 and VAMP-2 proteins were assessed using real-time qRT-PCR. Also, some biochemical parameters were examined, including fasting blood glucose, insulin levels and insulin resistance.Results: The results of this study showed that, resveratrol supplementation increased blood insulin level, reduced the fasting blood glucose, and improved the insulin resistance. In addition, resveratrol supplementation increased the expression of SNAP-23, syntaxin-4 and VAMP-2 proteins that involved in GLUT-4 transport in adipose tissue of diabetic rats.Conclusion: Final results showed that SNARE proteins expression is significantly reduced in diabetic rats and treatment with resveratrol supplementation is associated with the increased expression of these proteins.
کلیدواژه‌ها
GLUT4؛ SNAP23 Protein؛ Syntaxin-4 Protein؛ Vesicle-associated membrane Protein 2؛ Resveratro
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