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Langerhans Cell Histiocytosis Followed by Hodgkin Lymphoma: A Case Report | ||
| Iranian Journal of Medical Sciences | ||
| مقاله 14، دوره 40، شماره 3، مرداد 2015، صفحه 282-286 اصل مقاله (2.12 M) | ||
| نوع مقاله: Case Report(s) | ||
| نویسندگان | ||
| Akbar Safaei1؛ Mandana Bagheri* 1؛ Jahanbanoo Shahryari1؛ Sadat Noori1؛ Elmira Esmailzade2 | ||
| 1Department of Pathology, Molecular Pathology and Cytogenetic Ward, Shiraz University of Medical Sciences, Iran | ||
| 2Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| چکیده | ||
| Langerhans cell histiocytosis (LCH) is a rare neoplasm defined as the proliferation of bone marrow langerhans cells, which is a kind of dendritic cells. The major pathological features of LCH are expression of CD1a and S100 as well as Birbeck granules. Its presentation can differ from a mild bone lesion to a multi-systemic evolved malignant neoplasm; however, the latter outcome is almost rare. Thus, LCH is mostly known as a benign neoplasm. In this study, we present a case of LCH followed by Hodgkin lymphoma (HL). Accompaniment of this disease with malignant lymphoma is rare and considered as case report. Several cases in which malignant lymphoma occurred prior to LCH are reported; however, few cases can be found with LCH followed by malignant lymphomas. | ||
| کلیدواژهها | ||
| Langerhans cell histiosis؛ Hodgkin disease؛ Immunohistochemistry | ||
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